Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging

NEUROBIOLOGY OF AGING

卷:36

Article

Fjell, Anders M.^1,2  Sneve, Markus H.¹  Grydeland, Hakon¹  Storsve, Andreas B.¹  de Lange, Ann-Marie Glaso¹  Amlien, Inge K.¹  Rogeberg, Ole J.³  Walhovd, Kristine B.^1,2 

[1] Univ Oslo, Dept Psychol, Res Grp Lifespan Changes Brain & Cognit, N-0317 Oslo, Norway

[2] Oslo Univ Hosp, Dept Phys Med & Rehabil, Unit Neuropsychol, Oslo, Norway

[3] Ragnar Frisch Ctr Econ Res, Oslo, Norway

关键词: Episodic memory;    Resting-state;    Functional connectivity;    Atrophy;    Aging;    Default mode network;   

DOI  :  10.1016/j.neurobiolaging.2015.08.020

来源: Elsevier

【 摘 要 】

A major task of contemporary cognitive neuroscience of aging is to explain why episodic memory declines. Change in resting-state functional connectivity (rsFC) could be a mechanism accounting for reduced function. We addressed this through 3 studies. In study 1, 119 healthy participants (20-83 years) were followed for 3.5 years with verbal recall testing and magnetic resonance imaging. Independent of atrophy, recall change was related to change in rsFC in anatomically widespread areas. Striking ageeffects were observed in that a positive relationship between rsFC and memory characterized older participants while a negative relationship was seen among the younger and middle-aged. This suggests that cognitive consequences of rsFC change are not stable across age. In study 2 and 3, the age-dependent differences in rsFC-memory relationship were replicated by use of a simulation model (study 2) and by a cross-sectional experimental recognition memory task (study 3). In conclusion, memory changes were related to altered rsFC in an age-dependent manner, and future research needs to detail the mechanisms behind age-varying relationships. (C) 2015 Elsevier Inc. All rights reserved.

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