Determinants of cerebellar and cerebral volume in the general elderly population

NEUROBIOLOGY OF AGING

卷:33

Article

Hoogendam, Yoo Young^1,2  van der Geest, Jos N.³  van der Lijn, Fedde^2,4  van der Lugt, Aad²  Niessen, Wiro J.^2,4  Krestin, Gabriel P.²  Hofman, Albert¹  Vernooij, Meike W.^1,2  Breteler, Monique M. B.¹  Ikram, M. Arfan^1,2 

[1] Erasmus MC Univ, Med Ctr, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC Univ, Med Ctr, Dept Radiol, NL-3000 CA Rotterdam, Netherlands

[3] Erasmus MC Univ, Med Ctr, Dept Neurosci, NL-3000 CA Rotterdam, Netherlands

[4] Erasmus MC Univ, Med Ctr, Dept Med Informat, NL-3000 CA Rotterdam, Netherlands

关键词: Cohort study;    Cerebellum;    Cerebrum;    Aging;    Brain volume;    Magnetic resonance imaging;    Cerebrovascular disease;    Infarcts;    White matter lesions;    Cardiovascular risk factors;   

DOI  :  10.1016/j.neurobiolaging.2012.02.012

来源: Elsevier

【 摘 要 】

In a population-based study of 3962 community-dwelling nondemented elderly we investigated the relation of age, sex, cardiovascular risk factors, and the presence of infarcts with cerebellar volume, and its interrelationship with cerebral volumes. Cerebellar and cerebral gray and white matter were segmented using Freesurfer version 4.5 (http://surfer.nmr.mgh.harvard.edu/). We used linear regression analyses to model the relationship between age, sex, cardiovascular risk factors, brain infarcts, white matter lesions (WMLs) and cerebellar and cerebral volume. Smaller cerebellar volumes with increasing age were mainly driven by loss of white matter. Diabetes, higher serum glucose and lower cholesterol levels were related to smaller cerebellar volume. No association was found between hypertension, smoking, apolipoprotein E (ApoE) genotype, and cerebellar volume. Supratentorial lacunar infarcts and WMLs were related to smaller cerebellar volume. Infratentorial infarcts were related to smaller cerebellar white matter volume and total cerebral volume. This study suggests that determinants of cerebellar volume do not entirely overlap with those established for cerebral volume. Furthermore, presence of infarcts or WMLs in the cerebrum can affect cerebellar volume. (C) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

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