Longitudinal MRI atrophy biomarkers: Relationship to conversion in the ADNI cohort

NEUROBIOLOGY OF AGING

卷:31

Article

Risacher, Shannon L.²  Shen, Li^2,4  West, John D.³  Kim, Sungeun⁴  McDonald, Brenna C.³  Beckett, Laurel A.⁵  Harvey, Danielle J.⁵  Jack, Clifford R., Jr.⁶  Weiner, Michael W.^7,8,9,10  Saykin, Andrew J.^1,2,3 

[1] Indiana Univ, Sch Med, Dept Radiol & Imaging Sci, Ctr Neuroimaging, Indianapolis, IN 46202 USA

[2] Stark Neurosci Res Inst, Med Neurosci Program, Indianapolis, IN USA

[3] Indiana Alzheimer Dis Ctr, Indianapolis, IN USA

[4] Indiana Univ, Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA

[5] Univ Calif Davis, Sch Med, Div Biostat, Davis, CA 95616 USA

[6] Mayo Clin, Rochester, MN USA

[7] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

[8] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[9] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[10] Dept Vet Affairs Med Ctr, San Francisco, CA USA

关键词: Alzheimer's Disease Neuroimaging Initiative (ADNI);    Magnetic resonance imaging (MRI);    Voxel-based morphometry (VBM);    Mild cognitive impairment (MCI);    Hippocampus;    Longitudinal change;    Genetic factors;    Apolipoprotein E (APOE) epsilon 4 allele;   

DOI  :  10.1016/j.neurobiolaging.2010.04.029

来源: Elsevier

【 摘 要 】

Atrophic changes in early Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) have been proposed as biomarkers for detection and monitoring. We analyzed magnetic resonance imaging (MRI) atrophy rate from baseline to 1 year in 4 groups of participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI): AD (a = 152), converters from MCI to probable AD (MCI-C, a = 60), stable MCI (MCI-S, n = 261), and healthy controls (HC, n = 200). Scans were analyzed using multiple methods, including voxel-based morphometry (VBM), regions of interest (ROIs), and automated parcellation, permitting comparison of annual percent change (APC) in neurodegeneration markers. Effect sizes and the sample required to detect 25% reduction in atrophy rates were calculated. The influence of APOE genotype on APC was also evaluated. AD patients and converters from MCI to probable AD demonstrated high atrophy APCs across regions compared with minimal change in healthy controls. Stable MCI subjects showed intermediate atrophy rates. A POE genotype was associated with APC in key regions. In sum, APC rates are influenced by APOE genotype, imminent MCI to AD conversion, and AD-related neurodegeneration. (C) 2010 Elsevier Inc. All rights reserved.

【 授权许可】

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