Early Alzheimer's disease blocks responses to accelerating self-movement

NEUROBIOLOGY OF AGING

卷:33

Article

Duffy, Charles J.¹ 

[1] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA

关键词: Aging;    Alzheimer's disease;    Vision;    Motion;    Event related potentials;   

DOI  :  10.1016/j.neurobiolaging.2011.12.031

来源: Elsevier

【 摘 要 】

We assessed the cortical processing of self-movement stimuli in aging and Alzheimer's disease (AD). Our goal was to identify distinguishing effects on neural mechanisms related to driving and navigation. Young (YNC) and older (ONC) normal controls, and early AD patients (EAD) viewed real-world videos and dot motion stimuli simulating self-movement scenes. We recorded visual motion event related potentials (VMERPs) to stimulus motion coherence and speed. Aging delays motion evoked N200s, whereas AD diminishes response amplitudes. Early Alzheimer's disease patients respond to increments in motion coherence, but they are uniquely unresponsive to increments in motion speed that simulate accelerating self-movement. AD-related impairments of self-movement processing may have grave consequences for driving safety and navigational independence. (c) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

Free