Retinal thinning is uniquely associated with medial temporal lobe atrophy in neurologically normal older adults

NEUROBIOLOGY OF AGING

卷:51

Article

Casaletto, Kaitlin B.¹  Ward, Michael E.^1,2  Baker, Nicholas S.¹  Bettcher, Brianne M.^3,4  Gelfand, Jeffrey M.¹  Li, Yaqiao⁵  Chen, Robert¹  Dutt, Shubir¹  Miller, Bruce¹  Kramer, Joel H.¹  Green, Ari J.¹ 

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[2] NINDS, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[3] Univ Colorado, Dept Neurosurg, Rocky Mt Alzheimers Dis Ctr, Denver Anschutz Med Ctr, Aurora, CO USA

[4] Univ Colorado, Dept Neurol, Rocky Mt Alzheimers Dis Ctr, Denver Anschutz Med Ctr, Denver, CO USA

[5] Univ Calif San Francisco, Dept Neurol, Gladstone Inst Neurol Dis, San Francisco, CA USA

关键词: Aging;    Alzheimer ' s disease;    Optical coherence tomography;    Neurodegenerative disease;    Dementia;    Retinal imaging;   

DOI  :  10.1016/j.neurobiolaging.2016.12.011

来源: Elsevier

【 摘 要 】

Given the converging pathologic and epidemiologic data indicating a relationship between retinal integrity and neurodegeneration, including Alzheimer's disease (AD), we aimed to determine if retinal structure correlates with medial temporal lobe (MTL) structure and function in neurologically normal older adults. Spectral-domain optical coherence tomography, verbal and visual memory testing, and 3T-magnetic resonance imaging of the brain were performed in 79 neurologically normal adults enrolled in a healthy aging cohort study. Retinal nerve fiber thinning and reduced total macular and macular ganglion cell volumes were each associated with smaller MTL volumes (ps < 0.04). Notably, these markers of retinal structure were not associated with primary motor cortex or basal ganglia volumes (regions relatively unaffected in AD) (ps > 0.70), or frontal, precuneus, or temporoparietal volumes (regions affected in later AD Braak staging ps > 0.20). Retinal structure was not significantly associated with verbal or visual memory consolidation performances (ps > 0.14). Retinal structure was associated with MTL volumes, but not memory performances, in otherwise neurologically normal older adults. Given that MTL atrophy is a neuropathological hallmark of AD, retinal integrity may be an early marker of ongoing AD-related brain health. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

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