Association of amyloid pathology with memory performance and cognitive complaints in cognitively normal older adults: a monozygotic twin study

NEUROBIOLOGY OF AGING

卷:77

Article

Konijnenberg, Elles¹  den Braber, Anouk^1,2  ten Kate, Mara¹  Tomassen, Jori¹  Mulder, Sandra D.^1,3  Yaqub, Maqsood⁴  Teunissen, Charlotte E.³  Lammertsma, Adriaan A.⁴  van Berckel, Bart N. M.⁴  Scheltens, Philip¹  Boomsma, Dorret, I¹  Visser, Pieter Jelle^1,5 

[1] Vrije Univ Amsterdam Med Ctr, Dept Neurol & Alzheimer Ctr, Neurosci Amsterdam, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Dept Biol Psychol, Neurosci Amsterdam, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam Med Ctr, Dept Clin Biochem & Neurochem Lab, Neurosci Amsterdam, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam Med Ctr, Dept Radiol & Nucl Med, Neurosci Amsterdam, Amsterdam, Netherlands

[5] Maastricht Univ, Sch Mental Hlth & Neurosci, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

关键词: Memory performance;    Amyloid aggregation;    Monozygotic twins;    Cognitive complaints;   

DOI  :  10.1016/j.neurobiolaging.2019.01.006

来源: Elsevier

【 摘 要 】

Amyloid pathology in cognitively normal older adults has been associated with low memory performance and cognitive complaints, but findings are conflicting. Using a monozygotic twin design, we further explored this relation. We investigated 199 cognitively normal older adults (96 twin pairs) and assessed cognitive performance, cognitive complaints, and amyloid pathology on positron emission tomography and in the cerebrospinal fluid (CSF). Participants were on average 70.5 (SD = 7.6) years and 114 (57%) were female. Amyloid-positron emission tomography abnormality on visual read and lower CSFamyloid-beta 1-42/1-40 ratio were associated with lower Rey visuospatial memory performance (respectively, beta = -0.39 [SE = 0.17], p = 0.02 and beta = 0.15 [SE = 0.07], p = 0.04). Twin analyses showed that CSF amyloid-beta 1-42/1-40 ratio in one twin of a pair could predict visuospatial memory performance in the cotwin (r = 0.20 [SE = 0.10], p = 0.04). Monozygotic twin discordance analyses further showed a probable effect of disease staging on face-name associative memory performance. Our results suggest amyloid aggregation to be associated with lower visuospatial and face-name-associated memory performance in cognitively normal older adults, supporting the view that amyloid pathology leads to memory dysfunction in very early stages of the disease. (C) 2019 The Authors. Published by Elsevier Inc.

【 授权许可】

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