Changes in the intracellular microenvironment in the aging human brain

NEUROBIOLOGY OF AGING

卷:95

Article

Deelchand, Dinesh K.¹  McCarten, J. Riley^2,3  Hemmy, Laura S.^2,4  Auerbach, Edward J.¹  Eberly, Lynn E.⁵  Marjanska, Malgorzata¹ 

[1] Univ Minnesota, Dept Radiol, Ctr Magnet Resonance Res, Minneapolis, MN 55455 USA

[2] Vet Affairs Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Minneapolis, MN USA

[3] Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

[5] Univ Minnesota, Div Biostat, Minneapolis, MN USA

关键词: ADC;    Diffusion;    T-2;    Magnetic resonance spectroscopy;    Young;   

DOI  :  10.1016/j.neurobiolaging.2020.07.017

来源: Elsevier

【 摘 要 】

Normal brain aging is associated with changes occurring at all levels. This study investigates age-related differences in the brain intracellular microenvironment by comparing the apparent diffusion coefficients (ADC) and apparent transverse relaxation time constants (T-2) of 5 neurochemicals (i.e., total N-acetylaspartate, total creatine, total choline, glutamate, and myo-inositol) between young and older adults. Thirty-two young healthy adults (18-22 years) and 26 older healthy adults (70-83 years) were recruited. Three brain regions were studied at 3 T: prefrontal, posterior cingulate and occipital cortices. ADC and T-2 were measured using stimulated echo acquisition mode and localization by adiabatic selective refocusing sequences, respectively. This study shows that the diffusivities of several neurochemicals are higher in older than in younger adults. In contrast, shorter apparent T-2 values for several metabolites were measured in older adults. Age-related difference in ADC and apparent T-2 of metabolites seem to be region-specific. Furthermore, this study shows that it is feasible to observe age-related differences in the cellular microenvironment of neurochemicals in the normal aging brain. (C) 2020 Elsevier Inc. All rights reserved.

【 授权许可】

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