Cardiovascular risks and brain function: a functional magnetic resonance imaging study of executive function in older adults

NEUROBIOLOGY OF AGING

卷:35

Article

Chuang, Yi-Fang¹  Eldreth, Dana¹  Erickson, Kirk I.²  Varma, Vijay^1,3  Harris, Gregory³  Fried, Linda P.⁵  Rebok, George W.^1,3  Tanner, Elizabeth K.^3,4  Carlson, Michelle C.^1,3 

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD 21205 USA

[2] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

[3] Johns Hopkins Ctr Aging & Hlth, Baltimore, MD USA

[4] Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21205 USA

[5] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA

关键词: Cardiovascular risk;    Framingham risk score;    fMRI;    Brain function;    Executive function;    Older adults;   

DOI  :  10.1016/j.neurobiolaging.2013.12.008

来源: Elsevier

【 摘 要 】

Cardiovascular (CV) risk factors, such as hypertension, diabetes, and hyperlipidemia are associated with cognitive impairment and risk of dementia in older adults. However, the mechanisms linking them are not clear. This study aims to investigate the association between aggregate CV risk, assessed by the Framingham general cardiovascular risk profile, and functional brain activation in a group of community-dwelling older adults. Sixty participants (mean age: 64.6 years) from the Brain Health Study, a nested study of the Baltimore Experience Corps Trial, underwent functional magnetic resonance imaging using the Flanker task. We found that participants with higher CV risk had greater task-related activation in the left inferior parietal region, and this increased activation was associated with poorer task performance. Our results provide insights into the neural systems underlying the relationship between CV risk and executive function. Increased activation of the inferior parietal region may offer a pathway through which CV risk increases risk for cognitive impairment. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

Free