Depression and cardiovascular risk—association among Beck Depression Inventory, PCSK9 levels and insulin resistance

Cardiovascular Diabetology

A. Ceresa¹  M. Buoli²  C. Macchi³  C. R. Sirtori³  M. Ruscica³  G. Racagni³  A. Corsini⁴  N. Ferri⁵  C. Favero⁶  V. Bollati⁶  A. C. Pesatori⁶  D. M. Conti⁷  L. Vigna⁷ 

[1] Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy;Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy;Department of Neurosciences and Mental Health, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy;Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy;Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy;IRCCS, Multimedica, Sesto San Giovanni (Milan), Italy;Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, Padua, Italy;EPIGET Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy;Occupational Medicine Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy;

关键词: Beck Depression Inventory;    Cardiovascular risk;    Depression;    Framingham risk score;    Obesity;    Proprotein Converatse Subtilisin/Kexin type 9;   

DOI  :  10.1186/s12933-020-01158-6

来源: Springer

【 摘 要 】

BackgroundDepression and cardiovascular disease (CVD) are among the most common causes of disability in high-income countries, depression being associated with a 30% increased risk of future CV events. Depression is twice as common in people with diabetes and is associated with a 60% rise in the incidence of type 2 diabetes, an independent CVD risk factor. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a key regulator of low-density lipoprotein cholesterol, has been related to a large number of CV risk factors, including insulin resistance. Aim of this study was to investigate whether the presence of depression could affect PCSK9 levels in a population of obese subjects susceptible to depressive symptoms and how these changes may mediate a pre-diabetic risk.ResultsIn 389 obese individuals, the Beck Depression Inventory (BDI-II) was significantly associated with PCSK9 levels. For every one-unit increment in BDI-II score, PCSK9 rose by 1.85 ng/mL. Depression was associated also with the HOMA-IR (homeostatic model assessment index of insulin resistance), 11% of this effect operating indirectly via PCSK9.ConclusionsThis study indicates a possible mechanism linking depression and insulin resistance, a well-known CV risk factor, providing evidence for a significant role of PCSK9.

【 授权许可】

CC BY