Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein

NEUROBIOLOGY OF AGING

卷:60

Article

Tamagnini, Francesco¹  Walsh, Darren A.¹  Brown, Jon T.¹  Bondulich, Marie K.²  Hanger, Diane P.²  Randall, Andrew D.¹ 

[1] Univ Exeter, Med Sch, Inst Clin & Biomed Sci, Exeter, Devon, England

[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, Maurice Wohl Clin Neurosci Inst, London, England

关键词: Membrane electrical properties;    Neuronal excitability;    Synaptic plasticity;    Tauopathy;    Dementia;    Alzheimer's disease;    Progressive supranuclear palsy;    Hippocampus;   

DOI  :  10.1016/j.neurobiolaging.2017.07.005

来源: Elsevier

【 摘 要 】

The accumulation of cleaved tau fragments in the brain is associated with several tauopathies. For this reason, we recently developed a transgenic mouse that selectively accumulates a C-Terminal 35 kDa human tau fragment (Tau35). These animals develop progressive motor and spatial memory impairment, paralleled by increased hippocampal glycogen synthase kinase 3 beta activity. In this neurophysiological study, we focused on the CA1 subfield of the hippocampus, a brain area involved in memory encoding. The accumulation of Tau35 results in a significant increase of short-term facilitation of the synaptic response in the theta frequency range (10 Hz), without affecting basal synaptic transmission and long-term synaptic plasticity. Tau35 expression also alters the intrinsic excitability of CA1 pyramidal neurons. Thus, Tau35 presence is associated with increased and decreased excitability at hyperpolarized and depolarized potentials, respectively. These observations are paralleled by a hyperpolarization of the voltage-sensitivity of noninactivating K+ currents. Further investigation is needed to assess the causal link between such functional alterations and the cognitive and motor impairments previously observed in this model. (C) 2017 The Authors. Published by Elsevier Inc.

【 授权许可】

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