Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters

NEUROBIOLOGY OF AGING

卷:95

Article

Howell, Rebecca D.^1,2  Dominguez-Lopez, Sergio¹  Ocanas, Sarah R.^2,3  Freeman, Willard M.²  Beckstead, Michael J.¹ 

[1] Oklahoma Med Res Fdn, Aging & Metab Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK USA

[3] Oklahoma Med Res Fdn, Genes & Human Dis Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA

关键词: Electrophysiology;    Aging;    Mouse;    Dopamine;    Substantia nigra;    Firing;   

DOI  :  10.1016/j.neurobiolaging.2020.07.025

来源: Elsevier

【 摘 要 】

Degeneration of substantia nigra pars compacta dopamine neurons is a central feature in the pathology of Parkinson's disease, which is characterized by progressive loss of motor and cognitive functions. The largest risk factors for Parkinson's disease are age and sex; most cases occur after age 60 and males have nearly twice the incidence as females. Preclinical work has scarcely considered the influence of these 2 factors to disease risk and presentation. Here, we observed a progressive decline in dopamine neuron firing activity in male C57BL/6 mice by 18 months of age, while dopamine neurons from females remained largely unaffected. This was accompanied by increased mRNA expression of PINK1 in both males and females, and PARK2 primarily in males, both of which have been linked to Parkinson's. Since the declining cell properties were accompanied by only slight decreases in locomotion in both sexes, it is likely that these age-related impairments in males represent a vulnerability to further insults that could predispose the neurons to neurodegenerative processes such as in Parkinson's. (C) 2020 Elsevier Inc. All rights reserved.

【 授权许可】

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