Endocannabinoid modulation of dopaminergic motor circuits

Frontiers in Pharmacology

Cristina eMiguelez¹  Luisa eUgedo¹  Asier eAristieta¹  Teresa eMorera-Herreras²  José Ángel eRuiz-Ortega² 

[1] Faculty of Medicine and Dentistry. University of the Basque Country;Faculty of Pharmacy. University of the Basque Country;

关键词: Basal Ganglia;    Dopamine;    Electrophysiology;    Endocannabinoids;    Motor circuits;   

DOI  :  10.3389/fphar.2012.00110

来源: DOAJ

【 摘 要 】

There is substantial evidence supporting a role for the endocannabinoid system as a modulator of the dopaminergic activity in the basal ganglia, a forebrain system that integrates cortical information to coordinate motor activity regulating signals. In fact, the administration of plant-derived, synthetic or endogenous cannabinoids produces several effects on motor function. These effects are mediated primarily through the CB1 receptors that are densely located in the dopamine-enriched basal ganglia networks, suggesting that the motor effects of endocannabinoids are due, at least in part, to modulation of dopaminergic transmission.On the other hand, there are profound changes in CB1 receptor cannabinoid signaling in the basal ganglia circuits after dopamine depletion (as happens in Parkinson´s disease) and following L-DOPA replacement therapy. Therefore, it has been suggested that endocannabinoid system modulation may constitute an important component in new therapeutic approaches to the treatment of motor disturbances. In this article we will review studies supporting the endocannabinoid modulation of dopaminergic motor circuits.

【 授权许可】

Unknown