Effects of aging and calorie restriction on white matter in rhesus macaques

NEUROBIOLOGY OF AGING

卷:32

Article

Bendlin, B. B.^1,2  Canu, E.^1,2  Willette, A.^3,4  Kastman, E. K.^1,2  McLaren, D. G.^1,2  Kosmatka, K. J.^1,2  Xu, G.^1,2  Field, A. S.⁵  Colman, R. J.⁴  Coe, C. L.^3,4  Weindruch, R. H.^1,2,4  Alexander, A. L.^6,7,8  Johnson, S. C.^1,2 

[1] William S Middleton Mem Vet Adm Med Ctr, Geriatr Res Educ & Clin Ctr, Madison, WI 53705 USA

[2] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI USA

[3] Univ Wisconsin, Dept Psychol, Harlow Primate Lab, Madison, WI 53706 USA

[4] Wisconsin Natl Primate Res Ctr, Madison, WI USA

[5] Univ Wisconsin, Dept Radiol, Sch Med & Publ Hlth, Madison, WI 53706 USA

[6] Univ Wisconsin, Dept Psychiat, Sch Med & Publ Hlth, Madison, WI 53706 USA

[7] Univ Wisconsin, Dept Med Phys, Madison, WI 53706 USA

[8] Waisman Lab Brain Imaging & Behav, Madison, WI USA

关键词: Rhesus macaque;    Diffusion tensor imaging;    Magnetic resonance imaging;    Aging;    Caloric restriction;    White matter;   

DOI  :  10.1016/j.neurobiolaging.2010.04.008

来源: Elsevier

【 摘 要 】

Rhesus macaques on a calorie restricted diet (CR) develop less age-related disease, have virtually no indication of diabetes, are protected against sarcopenia, and potentially live longer. Beneficial effects of caloric restriction likely include reductions in age-related inflammation and oxidative damage. Oligodendrocytes are particularly susceptible to inflammation and oxidative stress, therefore, we hypothesized that CR would have a beneficial effect on brain white matter and would attenuate age-related decline in this tissue. CR monkeys and controls underwent diffusion tensor imaging (DTI). A beneficial effect of CR indexed by DTI was observed in superior longitudinal fasciculus, fronto-occipital fasciculus, external capsule, and brainstem. Aging effects were observed in several regions, although CR appeared to attenuate age-related alterations in superior longitudinal fasciculus, frontal white matter, external capsule, right parahippocampal white matter, and dorsal occipital bundle. The results, however, were regionally specific and also suggested that CR is not salutary across all white matter. Further evaluation of this unique cohort of elderly primates to mortality will shed light on the ultimate benefits of an adult-onset, moderate CR diet for deferring brain aging. Published by Elsevier Inc.

【 授权许可】

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