The association of mid-to late-life systemic inflammation with white matter structure in older adults: The Atherosclerosis Risk in Communities Study

NEUROBIOLOGY OF AGING

卷:68

Article

Walker, Keenan A.¹  Windham, B. Gwen²  Power, Melinda C.³  Hoogeveen, Ron C.^4,5  Folsom, Aaron R.⁶  Ballantyne, Christie M.^4,5  Knopman, David S.⁷  Selvin, Elizabeth^8,9  Jack, Clifford R., Jr.¹⁰  Gottesman, Rebecca F.^1,9 

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[2] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA

[3] George Washington Univ, Milken Inst, Sch Publ Hlth, Dept Epidemiol & Biostat, Washington, DC USA

[4] Baylor Coll Med, Cardiol Sect, Houston, TX 77030 USA

[5] Houston Methodist DeBakey Heart & Vasc Ctr, Ctr Cardiovasc Dis Prevent, Houston, TX USA

[6] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[7] Mayo Clin, Dept Neurol, Rochester, MN USA

[8] Johns Hopkins Univ, Sch Med, Dept Internal Med, Baltimore, MD USA

[9] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[10] Mayo Clin, Dept Radiol, Rochester, MN USA

关键词: Inflammation;    Brain;    White matter disease;    Aging;    Magnetic resonance imaging;    Diffusion tensor imaging;   

DOI  :  10.1016/j.neurobiolaging.2018.03.031

来源: Elsevier

【 摘 要 】

We examined whether the pattern of middle-to late-life systemic inflammation was associated with white matter (WM) structural abnormalities in older adults. A total of 1532 participants (age = 76.5; standard deviations = 5.4) underwent 3T brain magnetic resonance imaging to quantify white matter hyperintensity volume and whole-brain WM microstructural integrity (fractional anisotropy, mean diffusivity). High-sensitivity C-reactive protein (CRP), a marker of systemic inflammation, was measured at 3 visits (21 and 14 years before, and concurrent with, neuroimaging). Participants were categorized into 1 of 6 groups based on their 21-year pattern of low (<3 mg/L) versus elevated (>3 mg/L) CRP. Compared to the group with low CRP at all 3 visits, the group that transitioned from low to elevated CRP during midlife demonstrated greatest white matter hyperintensity volume and poorest WM microstructural integrity, after adjusting for demographic variables and cardiovascular risk factors. Participants with high CRP at all visits also demonstrated greater WM structural abnormalities, but only after accounting for differential attrition. These results suggest that increasing and persistent inflammation in the decades spanning middle-to late-life may promote WM disease in older adults. (C) 2018 Elsevier Inc. All rights reserved.

【 授权许可】

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