Thyroid function, the risk of dementia and neuropathologic changes: The Honolulu-Asia Aging Study

NEUROBIOLOGY OF AGING

卷:30

Article

de Jong, Frank Jan⁵  Masaki, Karnal³  Chen, Hepei¹  Remaley, Alan T.⁴  Breteler, Monique M. B.²  Petrovitch, Helen³  White, Lon R.³  Launer, Lenore J.¹ 

[1] NIA, Lab Epidemiol Demog & Biometry, NIH, Bethesda, MD 20892 USA

[2] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands

[3] Pacific Hlth Res Inst, Honolulu, HI 96813 USA

[4] NIH, Dept Lab Med, Bethesda, MD 20892 USA

[5] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 CA Rotterdam, Netherlands

关键词: Epidemiology;    Thyroid hormones;    Thyrotropin;    Total thyroxine;    Free thyroxine;    Dementia;    Alzheimer's disease;    Neuropathology;    Neuritic plaques;    Neurofibrillary tangles;   

DOI  :  10.1016/j.neurobiolaging.2007.07.019

来源: Elsevier

【 摘 要 】

Thyroid dysfunction is associated with cognitive impairment and dementia, including Alzheimer's disease (AD). It remains unclear whether thyroid dysfunction results from, or contributes to, Alzheimer pathology. We determined whether thyroid function is associated with dementia, specifically AD, and Alzheimer-type neuropathology in a prospective population-based cohort of Japanese-American men. Thyrotropin, total and free thyroxine were available in 665 men aged 71-93 years and dementia-free at baseline (1991), including 143 men who participated in an autopsy sub-study. During a mean follow-up of 4.7 (S.D.: 1.8) years, 106 men developed dementia of whom 74 had AD. Higher total and free thyroxine levels were associated with an increased risk of dementia and AD (age and sex adjusted hazard ratio (95% confidence interval) per S.D. increase in free thyroxine: 1.21 (1.04; 1.40) and 1.31 (1.14; 1.51), respectively). In the autopsied sub-sample, higher total thyroxine was associated with higher number of neocortical neuritic plaques and neurofibrillary tangles. No associations were found for thyrotropin. Our findings suggest that higher thyroxine levels are present with Alzheimer clinical disease and neuropathology. (C) 2007 Elsevier Inc. All rights reserved.

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