Hormone levels and cognitive function in postmenopausal midlife women

NEUROBIOLOGY OF AGING

卷:33

Article

Ryan, Joanne^2,3,4,5  Stanczyk, Frank Z.⁶  Dennerstein, Lorraine^2,3  Mack, Wendy J.⁷  Clark, Margaret S.²  Szoeke, Cassandra^2,3  Kildea, Daniel⁸  Henderson, Victor W.¹ 

[1] Stanford Univ, Dept Hlth Res & Policy Epidemiol, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[2] Univ Melbourne, Dept Psychiat, Parkville, Vic 3010, Australia

[3] Univ Melbourne, Natl Ageing Res Inst, Parkville, Vic 3010, Australia

[4] Univ Montpellier I, F-34000 Montpellier, France

[5] INSERM, U888, F-34093 Montpellier, France

[6] Univ So Calif, Dept Obstet & Gynecol, Keck Sch Med, Los Angeles, CA 90033 USA

[7] Univ So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA

[8] RMIT Univ Melbourne, Sch Math & Geospatial Sci, Melbourne, Vic 3000, Australia

关键词: Cognition;    Estradiol;    Estrone;    Menopause;    Memory;    Testosterone;   

DOI  :  10.1016/j.neurobiolaging.2010.07.014

来源: Elsevier

【 摘 要 】

Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women's Midlife Health Project cohort were administered a comprehensive battery of neuropsychological tests on two occasions 2 years apart. Participants (n = 148, mean age 60 years) had undergone natural menopause and were not using hormone therapy. Estrone, total and free estradiol, and total and free testosterone levels were measured at time of the first testing. Principal-component analysis identified four cognitive factors. In multiple linear regression analyses, better semantic memory performance was associated with higher total (p = 0.02) and free (p = 0.03) estradiol levels and a lower ratio of testosterone to estradiol (p = 0.007). There were trends for associations between better verbal episodic memory and lower total testosterone (p = 0.08) and lower testosterone/estradiol ratio (p = 0.06). Lower free testosterone levels were associated with greater 2-year improvement on verbal episodic memory (p = 0.04); higher testosterone/estradiol predicted greater semantic memory improvement (p = 0.03). In postmenopausal midlife women, endogenous estradiol and testosterone levels and the testosterone/estradiol ratio are associated with semantic memory and verbal episodic memory abilities. (C) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

Free