Age-related effects on the neural correlates of autobiographical memory retrieval

NEUROBIOLOGY OF AGING

卷:33

Article

Jacques, Peggy L. St.^1,2  Rubin, David C.²  Cabeza, Roberto^1,2 

[1] Duke Univ, Ctr Cognit Neurosci, Durham, NC 27708 USA

[2] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA

关键词: Aging;    fMRI;    Autobiographical memory;    Hippocampus;    Prefrontal cortex;    Episodic memory retrieval;    Effective connectivity;   

DOI  :  10.1016/j.neurobiolaging.2010.11.007

来源: Elsevier

【 摘 要 】

Older adults recall less episodically rich autobiographical memories (AM), however, the neural basis of this effect is not clear. Using functional MRI, we examined the effects of age during search and elaboration phases of AM retrieval. Our results suggest that the age-related attenuation in the episodic richness of AMs is associated with difficulty in the strategic retrieval processes underlying recovery of information during elaboration. First, age effects on AM activity were more pronounced during elaboration than search, with older adults showing less sustained recruitment of the hippocampus and ventrolateral prefrontal cortex (VLPFC) for less episodically rich AMs. Second, there was an age-related reduction in the modulation of top-down coupling of the VLPFC on the hippocampus for episodically rich AMs. In sum, the present study shows that changes in the sustained response and coupling of the hippocampus and prefrontal cortex (PFC) underlie age-related reductions in episodic richness of the personal past. (C) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

Free