Body mass trajectories and cortical thickness in middle-aged men: a 42-year longitudinal study starting in young adulthood

NEUROBIOLOGY OF AGING

卷:79

Article

Franz, Carol E.^1,2  Xian, Hong³  Lew, Daphne³  Hatton, Sean N.^1,2  Puckett, Olivia^1,2  Whitsel, Nathan^1,2  Beck, Asad⁴  Dale, Anders M.⁵  Fang, Bin^1,2  Fennema-Notestine, Christine^1,2,5  Hauger, Richard L.^1,2,6  Jacobson, Kristen C.⁷  Lyons, Michael J.⁸  Reynolds, Chandra A.⁹  Kremen, William S.^1,2,6 

[1] Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr,MC 0738, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Ctr Behav Genet Aging, La Jolla, CA 92093 USA

[3] St Louis Univ, Dept Epidemiol & Biostat, St Louis, MO 63103 USA

[4] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA

[5] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA

[6] VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA USA

[7] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA

[8] Boston Univ, Dept Psychol & Brain Sci, Boston, MA 02215 USA

[9] Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA

关键词: Obesity;    Body mass index (BMI);    Trajectory;    Longitudinal;    Cortical thickness;    White matter abnormalities;   

DOI  :  10.1016/j.neurobiolaging.2019.03.003

来源: Elsevier

【 摘 要 】

Evidence strongly suggests that being overweight or obese at midlife confers significantly higher risk for Alzheimer's disease and greater brain atrophy later in life. Few studies, however, examine associations between longitudinal changes in adiposity during early adulthood and later brain morphometry. Measures of body mass index (BMI) were collected in 373 men from the Vietnam Era Twin Study of Aging at average ages 20, 40, 56, and 62 years, yielding 2 BMI trajectories. We then examined associations between BMI phenotypes (trajectories, continuous BMI, obese/nonobese), cortical thickness, and white matter measures from structural magnetic resonance imaging at mean age 62 (time 4, range 56-66 years). Those on the obesity trajectory (N = 171) had a thinner cortex compared with the normal/lean trajectory (N = 202) in multiple frontal and temporal lobe bilateral regions of interest: superior, inferior, middle temporal gyri, temporal pole, fusiform gyrus, banks of the superior temporal sulcus, frontal pole, pars triangularis, caudal and rostral middle frontal gyri (all p < 0.05, false discovery rate corrected). Frontal lobe thinness tended to occur mainly in the right hemisphere. Results were similar for obese versus nonobese adults at age 62. There were no significant differences for white matter volume or abnormalities. Taken in the context of other research, these associations between brain structures and excess BMI at midlife suggest potential for increased risk for cognitive decline in later life. (C) 2019 Elsevier Inc. All rights reserved.

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