Pregnancy outcome according to male diagnosis after ICSI with non-ejaculated sperm compared with ejaculated sperm controls

REPRODUCTIVE BIOMEDICINE ONLINE

卷:29

Article

Oldereid, Nan B.¹  Hanevik, Hans I.²  Bakkevig, Inga³  Romundstad, Liv B.^4,5  Magnus, Oystein⁶  Hazekamp, Johan⁷  Hentemann, Martha⁸  Eikeland, Snorre N.⁹  Skrede, Siren¹⁰  Reitan, Ingeborg R.¹¹  Tanbo, Tom G.^1,12 

[1] Oslo Univ Hosp, Dept Gynaecol, N-0424 Oslo, Norway

[2] Fertilitetsklinikken Sor, N-3901 Porsgrunn, Norway

[3] Helse Fonna HF, N-5504 Haugesund, Norway

[4] St Olavs Univ Hosp, Fertil Clin, Dept Obstet & Gynecol, Trondheim, Norway

[5] NTNU, Dept Publ Hlth, Trondheim, Norway

[6] Aleris Hosp, Fertil Ctr, N-0264 Oslo, Norway

[7] IVF Klinikken Oslo AS, N-0301 Oslo, Norway

[8] Univ Hosp Northern Norway, Dept Obstet & Gynecol, N-9019 Tromso, Norway

[9] KlinikkHausken, N-5531 Haugesund, Norway

[10] Haukeland Hosp, Dept Obstet & Gynaecol, N-5053 Bergen, Norway

[11] Medicus, N-7013 Trondheim, Norway

[12] Univ Oslo, Inst Clin Med, N-0424 Oslo, Norway

关键词: aspermia;    azoospermia;    congenital malformations;    PESA;    TESA;    TESE;   

DOI  :  10.1016/j.rbmo.2014.06.009

来源: Elsevier

【 摘 要 】

The aim of this study was to describe pregnancy outcome in couples who had undergone ICSI using non-ejaculated sperm from men with non-obstructive azoospermia, obstructive azoospermia and aspermia compared with the outcome of ICSI with ejaculated sperm from men with severe oligozoospermia, treated during the same time period. This nationwide cohort study included all children born after ICSI with non-ejaculated sperm in Norway, from when the method was first permitted in Norway in April 2004 to the end of 2010, resulting in 420 pregnancies and a total of 359 children. In 235 of these children, the father was diagnosed with obstructive azoospermia, in 72 with non-obstructive azoospermia, in 31 with aspermia, and in 21 the male cause was unclassifiable. The control group consisted of 760 children from 939 pregnancies conceived by ICSI with ejaculated sperm. Sex ratio, birth weight, rate of pregnancy loss and congenital malformations were not significantly associated with sperm origin or the cause of male factor infertility. (C) 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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