Depression and state anxiety scores during assisted reproductive treatment are associated with outcome: a meta-analysis

REPRODUCTIVE BIOMEDICINE ONLINE

卷:36

Review

Purewal, Satvinder¹  Chapman, Sarah C. E.²  van den Akker, Olga B. A.³ 

[1] Univ Wolverhampton, Fac Educ Hlth & Wellbeing, Inst Psychol, Wolverhampton WV1 1AD, W Midlands, England

[2] Univ Bath, Dept Pharm & Pharmacol, Claverton Down Rd, Bath BA2 7AY, Avon, England

[3] Middlesex Univ, Fac Sci & Technol, Dept Psychol, London NW4 4BT, England

关键词: Anxiety;    Assisted reproductive technology;    Depression;    Infertility;    Psychology;   

DOI  :  10.1016/j.rbmo.2018.03.010

来源: Elsevier

【 摘 要 】

This meta-analysis investigated whether state anxiety and depression scores during assisted reproductive technology (ART) treatment and changes in state anxiety and depression scores between baseline and during ART treatment are associated with treatment outcome. PubMed, PsycInfo, Embase, ScienceDirect, Web of Science and Scopus were searched and meta-analytic data analysed using random effects models to estimate standardized mean differences. Eleven studies (2202 patients) were included. Women who achieved pregnancy had significantly lower depression scores during treatment than women who did not become pregnant (-0.302; 95% CI: -0.551 to -0.054, z = -2.387, P = 0.017; I-2 = 77.142%, P = 0.001). State anxiety scores were also lower in women who became pregnant (-0.335; 95% CI: -0.582 to -0.087, z = -2.649, P = 0.008; I-2 = 81.339%, P = 0.001). However, changes in state anxiety (d = -0.056; 95% CI: -0.195 to 0.082, z = -0.794; I-2 = 0.00%) and depression scores (d = -0.106; 95% CI: -0.296 to 0.085, z = -1.088; I-2 = 0.00%) from baseline to treatment were not associated with ART outcome. Clinics should aim to promote better psychosocial care to help patients manage the psychological and physical demands of ART treatment, giving realistic expectations. Crown Copyright (C) 2018 Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd. All rights reserved.

【 授权许可】

Free