Prevalence and associated factors of erectile dysfunction, psychological disorders, and sexual performance in primary vs. secondary infertility men

Reproductive Biology and Endocrinology

Binghao Bao¹  Haisong Li¹  Bin Wang¹  Wangqiang Chen²  Yingying Zhang³  Jianxiong Ma⁴ 

[1] Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China;Department of Reproductive Medicine, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital, Hangzhou, China;The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China;The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China;Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China;Key Laboratory of Integrative Chinese and Western Medicine for Prevention and Treatment of Sexual Dysfunction of Zhejiang Province, Hangzhou, China;

关键词: Infertility;    Erectile dysfunction;    Depression;    Anxiety;    Risk factors;   

DOI  :  10.1186/s12958-021-00720-5

来源: Springer

【 摘 要 】

BackgroundMany infertile couples might experience erectile dysfunction (ED) and significant changes in the quality of sexual life and psychological state though information is limited in secondary infertile men in China. To determine whether primary or secondary infertility is associated with ED, psychological disorders, and sexual performance.MethodsThis was a cross-sectional survey conducted at the Dongzhimen Hospital of Beijing University of Chinese Medicine (06/2019-01/2020). The participants completed a questionnaire including general information, sexual life, simplified International Index of Erectile Function (IIEF-5), Patient Health Questionnaire-9 (PHQ-9), and 7-item Generalized Anxiety Disorder Scale (GAD-7). Multivariable logistic regression was used to identify the factors associated with ED, depression, and anxiety.ResultsED was more frequent in secondary vs. primary infertility (46.5 % vs. 26.7 %, P < 0.001). Compared with men with primary infertility, those with secondary infertility showed lower IIEF-5 scores (P < 0.001), higher occurrence of TOIF (P = 0.001), had a higher awareness of partner’s ovulation when having ED (P = 0.001), lower GAD-7 scores (P = 0.016), lower libido (P = 0.005), fewer intercourses per month (P = 0.001) and a lower sexual satisfaction score (P = 0.027). In the multivariate analysis, primary infertility was found to be an independent risk factor of anxiety (OR: 1.812, 95 %CI: 1.015–3.236). Some overlap is observed in factors associated with ED, psychological disorders, and sexual performance between primary and secondary infertility, but some factors are distinct.ConclusionsThe prevalence of ED in secondary infertility men was higher than that of primary infertility men, and the quality of sexual life was decreased. Primary infertility is an independent risk factor of anxiety.

【 授权许可】

CC BY