Assessment of presence and characteristics of multipotent stromal cells in human endometrium and decidua

REPRODUCTIVE BIOMEDICINE ONLINE

卷:20

Review

Kyurkchiev, Stanimir¹  Shterev, Atanas²  Dimitrov, Rumen¹ 

[1] Bulgarian Acad Sci, Inst Biol & Immunol Reprod Acad K Bratanov, BU-1113 Sofia, Bulgaria

[2] Ob Gyn Hosp Dr Shterev, IVF Unit, Sofia 1330, Bulgaria

关键词: decidua;    differentiation potential;    human endometrium;    immunomodulatory proteins;    multipotent stromal cells;   

DOI  :  10.1016/j.rbmo.2009.12.011

来源: Elsevier

【 摘 要 】

This review discusses the presence and characteristics of multipotent stromal cells in human endometrium and decidua. A number of research groups have reported the isolation and characterization of multipotent stromal cells from the basal layer of the endometrium, and in a single case just from the menstrual blood, i.e. the superficial functional layer. Similarly, multipotent pre-decidual stromal cells are isolated from early decidua and characterized accordingly. Multipotent endometrial stromal cells and multipotent decidual stromal cells are shown to express the basic features of adult stem cells, which are clonogenicity, self-renewal, a potential to differentiate into adipogenic, osteogenic, chrondrogenic, endothelial-like cells and a specific set of surface molecules (CD73, CD90 and CD105). So far, it is not clear whether the same population of multipotent stromal cells is isolated from the basal endometrium or early decidua because it has been shown that in some cases the differentiation potential of endometrial stromal cells is more restricted in comparison to the decidual stromal cells. It is reasonable to assume that it is one cell population under different control by hormonal, paracrine and autocrine factors. Thus far, the functions of these cells have not been convincingly revealed. (C) 2009, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free