Depot GnRH-agonist trigger for breast-cancer patient undergoing ovarian stimulation resulted in mature oocytes for cryopreservation: a case report

REPRODUCTIVE BIOMEDICINE ONLINE

卷:22

Article

Cavagna, Mario¹ 

[1] Hosp Perola Byington, Womens Hlth Reference Ctr, Human Reprod Div, Sao Paulo, Brazil

关键词: fertility preservation;    GnRH agonist;    GnRH antagonist;    oocyte cryopreservation;    ovarian stimulation;   

DOI  :  10.1016/j.rbmo.2010.11.015

来源: Elsevier

【 摘 要 】

This report describes the case of a 27-year-old woman with breast cancer who underwent ovarian stimulation for fertility preservation with recombinant FSH in conjunction with a gonadotrophin-releasing hormone (GnRH) antagonist and an aromatase inhibitor from the beginning of the treatment. A 3.75-mg triptorelin depot formulation was given intramuscularly when the follicular diameter of three follicles reached >= 20 mm and a total of 13 follicles reached >= 15 mm. Oocyte retrieval was scheduled for 36 h later and 10 mature oocytes were collected and vitrified. This case report demonstrates that a depot GnRH-agonist trigger effectively leads to mature oocyte retrieval, with the advantage of initiating ovarian suppression for the purpose of fertility preservation during adjuvant chemotherapy in breast-cancer patients. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free