Feasibility of fertility preservation in young females with Turner syndrome

REPRODUCTIVE BIOMEDICINE ONLINE

卷:18

Article

Lau, Nga Man¹  Huang, Jack Yu Jen¹  MacDonald, Suzanne²  Elizur, Shai¹  Gidoni, Yariv¹  Holzer, Hananel¹  Chian, Ri-Cheng¹  Tulandi, Togas¹  Tan, Seang Lin¹ 

[1] McGill Univ, Dept Obstet & Gynecol, McGill Univ Hlth Ctr, Montreal, PQ H3A 1A1, Canada

[2] McGill Univ, Dept Pediat, McGill Univ Hlth Ctr, Montreal, PQ H3A 1A1, Canada

关键词: 45X;    fertility preservation;    FSH;    oocyte cryopreservation;    premature ovarian failure;    Turner syndrome;   

DOI  :  10.1016/S1472-6483(10)60268-4

来源: Elsevier

【 摘 要 】

Women with Turner syndrome (TS) are at risk of premature ovarian failure. The objective of this retrospective study was to identify patients with TS who could be potential candidates for fertility preservation and to determine their present reproductive and fertility status. Criteria for fertility preservation included: (i) spontaneous menarche; (ii) confirmation by ultrasound examination of the presence of at least one normal ovary; and (iii) serum FSH concentrations below 40 IU/l. Using the Montreal Children's Hospital Cytogenetic Database from 1990 to 2006, 28 patients with complete or partial absence of one X chromosome were identified: 13 (46%) were 45% nine (32%) had mosaic karyotypes; and six (21%) had karyotypes containing isochromosome or ring X chromosome. Six patients (21%)had spontaneous pubertal development and four (14%) were identified as potential candidates for fertility preservation. One underwent an ovarian stimulation protocol of gonadotrophin-releasing hormone agonist down-regulation followed by recombinant FSH and human menopausal gonadotrophin stimulation. Two metaphase-II-stage oocytes were aspirated and vitrified using the McGill Cryoleaf vitrification system. Another patient conceived spontaneously at the age of 24 years. In conclusion, fertility preservation may not be feasible for most patients with TS. However, after careful consideration of increased pregnancy-associated risks, fertility preservation may be offered to young females with mosaic TS.

【 授权许可】

Free