Assessing embryo viability by measurement of amino acid turnover

REPRODUCTIVE BIOMEDICINE ONLINE

卷:17

Article; Proceedings Paper

Sturmey, Roger G.¹  Brison, Daniel R.²  Leese, Henry J.¹ 

[1] Univ York, Dept Biol Area 3, York YO10 5YW, N Yorkshire, England

[2] St Marys Hosp, Dept Reprod Med, Manchester M13 0JH, Lancs, England

关键词: animal;    culture media;    human;    IVF;    profiling;    selection;   

DOI  :  10.1016/S1472-6483(10)60234-9

来源: Elsevier

【 摘 要 】

This review assesses the ability of non-invasive 'amino acid profiling' to predict early embryo viability. The history of amino acid supplementation of embryo culture media and the role of amino acids in early embryo development are first considered and these are followed by a review of methods to quantify amino acid depletion and production by single embryos. Data oil amino acid profiling of embryos from a number of species are then discussed. It is concluded that this technology has excellent potential to improve the selection of single embryos for transfer in clinical IVF.

【 授权许可】

Free