Bisphenol A, oocyte maturation, implantation, and IVF outcome: review of animal and human data

REPRODUCTIVE BIOMEDICINE ONLINE

卷:29

Review

Machtinger, Ronit¹ 

[1] Chaim Sheba Med Ctr, Dept Obstet & Gynecol, Infertil & IVF Unit, IL-52621 Tel Hashomer, Israel

关键词: bisphenol A;    endocrine disruptors;    folliculogenesis;    IVF;    meiosis;   

DOI  :  10.1016/j.rbmo.2014.06.013

来源: Elsevier

【 摘 要 】

Recent data have raised concerns about the detrimental effect of chronic exposure to environmental chemicals. Some chemicals affect the endocrine system (endocrine disruptors) and have been linked to several diseases, including infertility. One such endocrine disruptor is bisphenol A (BPA), a monomer widely used in the plastic industry, with nearly ubiquitous exposure. In this review, data on the effects of BPA on female fertility are summarized. Specifically, its effect is considered on folliculogenesis, oocyte maturation, embryo quality, and implantation, both in animal and human models. Animal studies have shown that BPA might impair prophase I, follicular growth, and implantation, and may be associated with spindle abnormalities. In humans, while in-vitro studies have suggested an association between BPA exposure and impaired oocyte meiosis, clinical evidence indicate possible adverse effects of BPA exposure on IVF outcomes. As human clinical data are still scarce, larger studies are required to further elucidate the effects of BPA exposure on female fertility. (C) 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free