Serum inhibin A concentration in women with polycystic ovarian syndrome and the correlation to ethnicity, androgens and insulin resistance

REPRODUCTIVE BIOMEDICINE ONLINE

卷:20

Article

Segal, Shimon^1,3  Elmadjian, Malvina¹  Takeshige, Takeko¹  Karp, Steven¹  Mercado, Ray¹  Rivnay, Benjamin² 

[1] Lincoln Med Ctr, Dept Obstet & Gynecol, Div Reprod Med, Bronx, NY 10451 USA

[2] Cornell Univ, Weill Med Coll, Ithaca, NY 14853 USA

[3] Repromedix Corp, Woburn, MA USA

关键词: Caucasian;    ethnicity;    Hispanic;    inhibin A;    polycystic ovarian syndrome;   

DOI  :  10.1016/j.rbmo.2010.02.006

来源: Elsevier

【 摘 要 】

A prospective case-series in an academic hospital clinic was performed to determine whether there is a relationship between polycystic ovarian syndrome (PCOS) and ethnicity. Also, serum inhibin A concentrations were compared between PCOS and normal-ovulatory women. The possibility of a correlation between inhibin A, androgens and insulin resistance in PCOS women was evaluated. Serum inhibin A concentrations were measured in anovulatory PCOS patients (n = 32) and in control women of reproductive age (n = 16). Statistical analysis was performed using the Mann Whitney U-test. Serum concentrations of inhibin A, follicle-stimulating hormone, LH, prolactin, thyroid-stimulating hormone, fasting glucose, insulin, testosterone, 17-hydroxyprogesterone (17-OHP) and dehydroepiandrosterone sulphate (DHEAS) were measured. Inhibin A concentrations were significantly lower (4.5 +/- 4.8 pg/ml) when compared with the control group (13.2 +/- 14.4 pg/ml; P = 0.003) and were not significantly different between Hispanic and Caucasian women diagnosed with PCOS. There was no correlation between inhibin A concentrations and insulin, testosterone, free testosterone, 17-OHP, or DHEAS concentrations. In PCOS women, inhibin A concentrations are similar between Hispanic and Caucasian women; however, women with PCOS, regardless of ethnicity, have a lower inhibin A concentration compared with normal-ovulatory women. No correlation was observed between inhibin A androgens and insulin resistance in women diagnosed with PCOS. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free