Significant correlation between anti-mullerian hormone and embryo euploidy in a subpopulation of infertile patients

REPRODUCTIVE BIOMEDICINE ONLINE

卷:35

Article

Gat, Itai^1,2,3,4,5  AlKudmani, Basheer^1,2,3  Wong, Karen¹  Zohni, Khaled^1,2,3  Weizman, Noga Fuchs^1,2,3  Librach, Clifford^1,2,3,6  Sharma, Prati^1,2,3,6 

[1] CReATe Fertil Ctr, Toronto, ON, Canada

[2] Univ Toronto, Dept Obstet & Gynecol, Toronto, ON, Canada

[3] Womens Coll Hosp, Dept Gynecol, Toronto, ON, Canada

[4] Sheba Med Ctr, Pinchas Borenstein Talpiot Med Leadership Program, Tel Hashomer, Israel

[5] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel

[6] Univ Toronto, Fac Med, Toronto, ON, Canada

关键词: Anti-Mullerian hormone;    Array comparative genomic;    hybridization;    Embryo euploidy;    Pre-implantation genetic screening;   

DOI  :  10.1016/j.rbmo.2017.06.027

来源: Elsevier

【 摘 要 】

Anti-Mullerian hormone (AMH) is a standard marker of ovarian reserve. Correlation between AMH and egg euploidy is controversial. We evaluated the association between AMH and blastocyst euploidy rate examined by pre-implantation genetic screening (PGS). This retrospective study was conducted at the CReATe Fertility Centre. We included single IVF cycles of 216 infertile couples, which resulted in 911 blastocysts subjected to array comparative genomic hybridization and evaluated IVF outcome after embryo transfer. The average age and median AMH of female patients were 37.2 (SD = 3.8) and 20 pmol/l, respectively, and the average euploidy rate was 38.3%. Using multivariate regression controlling for age, antral follicle count, body mass index and parity, there was a significant association between serum AMH and proportion of euploid embryos (P = 0.02), due to the dominant = 36 age group in which significant correlation between AMH and euploidy rate (P = 0.02) was demonstrated. Clinical outcome was similar, including biochemical, clinical and ongoing pregnancy rates as well as pregnancy loss. This study shows a correlation between AMH and aneuploidy rate, specifically among infertile patients younger than 37 years old. Study limitations are discussed. (C) 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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