Ovarian theca cells in follicular function

REPRODUCTIVE BIOMEDICINE ONLINE

卷:15

Review

Tajima, Kimihisa ; Orisaka, Makoto ; Mori, Takahicle ; Kotsuji, Fumikazu

关键词: atresia;    folliculogenesis;    oogenesis;    steroidogenesis;    theca cell;    theca-granulosa interaction;   

DOI  :  10.1016/S1472-6483(10)60392-6

来源: Elsevier

【 摘 要 】

The role of theca cells in every aspect of ovarian follicular function is reviewed. A distinguishing feature of theca cells may be their ability to initiate follicle growth on differentiation from cortical stromal cells, stimulate follicle growth by granulosa cell mitosis through FSH-induced androgen receptor, and cause androgen-stimulated receptor formation of FSH. As LH not only stimulates androgen production by theca cells at tonic levels, but also induces morphological luteinization in addition to androgenesis at surge levels, the dual action concept of LH is proposed. Maturation of the selected dominant follicle and atresia of subordinate antral follicles is interpreted by this concept. Two-way signalling between oocytes and somatic theca cells with growth factors is shown to play a pivotal role in preantral folliculogenesis and atresia. Thus, theca cells have a more significant role in follicular function than previously thought.

【 授权许可】

Free