Mild COVID-19 infection does not alter the ovarian reserve in women treated with ART

REPRODUCTIVE BIOMEDICINE ONLINE

卷:43

Article

Kolanska, Kamila^1,2  Hours, Alice¹  Jonquiere, Laurie¹  d'Argent, Emmanuelle Mathieu¹  Dabi, Yohann¹  Dupont, Charlotte^2,3  Touboul, Cyril^1,2  Antoine, Jean-Marie¹  Chabbert-Buffet, Nathalie^1,2  Darai, Emile^1,2 

[1] Sorbonne Univ, Hop Tenon, AP HP, Serv Gynecol Obstet & Med Reprod, 4 Rue Chine, F-75020 Paris, France

[2] Ctr Rech St Antoine, INSERM, UMRS 938, 27 Rue Chaligny, F-75571 Paris 12, France

[3] Sorbonne Univ, Hop Tenon, AP HP, Serv Biol Reprod CECOS, 4 Rue Chine, F-75020 Paris, France

关键词: AMH;    ART;    COVID;    Ovarian reserve;   

DOI  :  10.1016/j.rbmo.2021.09.001

来源: Elsevier

【 摘 要 】

Research question: Does mild COVID-19 infection affect the ovarian reserve of women undergoing an assisted reproductive technology (ART) protocol? Design: A prospective observational study was conducted between June and December 2020 at the ART unit of Tenon Hospital, Paris. Women managed at the unit for fertility issues by in-vitro fecundation, intracytoplasmic sperm injection (IVF/ICSI), fertility preservation, frozen embryo transfer or artificial insemination, and with an anti-Mullerian hormone (AMH) test carried out within 12 months preceding ART treatment, were included. All the women underwent a COVID rapid detection test (RDT) and AMH concentrations between those who tested positive (RDT positive) and those who tested negative (RDT negative). Results: The study population consisted of 118 women, 11.9% (14/118) of whom were COVID RDT positive. None of the tested women presented with a history of severe COVID-19 infection. The difference between the initial AMH concentration and AMH concentration tested during ART treatment was not significantly different between the COVID RDT positive group and COVID RDT negative group (-1.33 ng/ml [-0.35 to -1.61) versus -0.59 ng/ml [-0.15 to -1.11], P = 0.22). Conclusion: A history of mild COVID-19 infection does not seem to alter the ovarian reserve as evaluated by AMH concentrations. Although these results are reassuring, further studies are necessary to assess the effect of COVID-19 on pregnancy outcomes in women undergoing ART.

【 授权许可】

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