Effect of cigarette smoking upon reproductive hormones in women of reproductive age: a retrospective analysis

REPRODUCTIVE BIOMEDICINE ONLINE

卷:20

Article

Waylen, A. L.¹  Jones, G. L.²  Ledger, W. L.³ 

[1] Univ Sheffield, Sch Med & Biomed Sci, Sheffield S10 2RX, S Yorkshire, England

[2] ScHARR, Hlth Serv Res Sect, Sheffield S1 4DA, S Yorkshire, England

[3] Jessop Wing Hosp, Acad Unit Reprod & Dev Med, Sheffield S10 2TJ, S Yorkshire, England

关键词: cigarette;    infertility;    inhibin B;    ovarian reserve;    smoking;   

DOI  :  10.1016/j.rbmo.2010.02.021

来源: Elsevier

【 摘 要 】

There is continuing debate concerning the relationship between cigarette smoking and premature ovarian failure. The aim of this retrospective data analysis was to investigate whether smoking has a measurable effect on early follicular serum concentrations of inhibin B hormone, FSH and anti-Mullerian hormone (AMH) in women of reproductive age. A database containing data on age, smoking status and serum concentrations of inhibin B, FSH and AMH was analysed. Pearson's correlation coefficient was calculated to determine the correlation between hormone concentrations and age. One-way analysis of variance was used to determine any significant difference in age between smoking categories and a univariate general linear model was used to compare geometric means and geometric mean ratios of hormone concentrations in relation to smoking status. Serum concentrations of inhibin B were significantly lower in women who had ever smoked cigarettes: F(2,332) = 3.371, P = 0.036. There was no statistically significant difference in FSH or AMH concentrations although a trend towards lower AMH concentrations in smokers was observed. This analysis provides evidence of an advancement of ovarian ageing in women who smoke cigarettes and is relevant to women of childbearing age who wish to avoid premature decline in fertility. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free