Probability of live birth in women with extremely low anti-Mullerian hormone concentrations

REPRODUCTIVE BIOMEDICINE ONLINE

卷:28

Article

Lukaszuk, Krzysztof^1,2,3,4  Kunicki, Michal⁵  Liss, Joanna²  Bednarowska, Alicja⁵  Jakiel, Grzegorz^5,6 

[1] Med Univ, Dept Perinatol, Gdansk, Poland

[2] INVICTA Fertil & Reprod Ctr, Gdansk, Poland

[3] Med Univ Gdansk, Fac Hlth Sci, Dept Obstet & Gynecol Nursing, Gdansk, Poland

[4] Univ Varmia & Masuria, Fac Med Sci, Dept Obstet & Gynecol, Olsztyn, Poland

[5] INVICTA Fertil & Reprod Ctr, Warsaw, Poland

[6] Med Ctr Postgrad Educ, Dept Obstet & Gynaecol, Warsaw, Poland

关键词: AMH;    endometriosis;    inhibin B;    ovarian reserve;    DHEA;    IVF;   

DOI  :  10.1016/j.rbmo.2013.09.017

来源: Elsevier

【 摘 要 】

The aim of the present study was to investigate the clinical pregnancy and live birth rates in women with extremely low (<= 0.4 ng/ml) anti-Mullerian hormone (AMH) concentrations. The study included 101 women (188 cycles) with extremely low AMH concentrations undergoing IVF cycles and compared the number of live births in women with low AMH. Moreover, the study compared the number of live births in women with or without endometriosis stage III/IV. Fourteen clinical pregnancies and 14 live births (including one pair of twins) were recorded; one woman miscarried. Significantly higher clinical pregnancy (P = 0.046) and live birth rates (P = 0.018) were found in women aged <35 years compared with older women. AMH concentration did not differ significantly between women with or without endometriosis and there were six live births in women with endometriosis. This was not significantly different from the rate in healthy women. It is concluded that live births are possible in women with extremely low AMH concentrations. The presence of endometriosis stage III/IV did not affect live birth rates in women with extremely low AMH concentrations although an important limitation of the study is the small number of women included who were affected by that disease. (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free