Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples

REPRODUCTIVE BIOMEDICINE ONLINE

卷:23

Article

Pinborg, A.¹  Gaarslev, C.²  Hougaard, C. O.²  Andersen, A. Nyboe¹  Andersen, P. K.²  Boivin, J.³  Schmidt, L.² 

[1] Univ Copenhagen, Rigshosp, Fertil Clin, Juliane Marie Ctr, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Dept Publ Hlth, DK-2100 Copenhagen, Denmark

[3] Cardiff Univ, Cardiff Fertil Studies Res Grp, Sch Psychol, Cardiff, Wales

关键词: body mass index;    IVF outcome;    live-birth rate;    obesity;    overweight;   

DOI  :  10.1016/j.rbmo.2011.06.010

来源: Elsevier

【 摘 要 】

This study investigated the impact of women's body mass index (BMI) on the outcome after consecutive IVF/intracytoplasmic sperm injection cycles in 487 patients initiating treatment with 5-year follow-up. The total number of cycles was 1417. In total 103 (21.1%) were overweight (BMI 25-29.9 kg/m(2)) and 59 (12.1%) were obese (BMI >= 30 kg/m(2)). Number of initiated cycles/woman (P = 0.01), number of cancelled cycles/woman (P < 0.01) and the total dose of gonadotrophin used/cycle (P < 0.01) rose with increasing BMI. A negative linear association between BMI and the number of retrieved oocytes (B = -0.243, P < 0.001) and an inverse U-shaped relationship between BMI and the number of developed embryos was seen, with less embryos available among underweight and obese women (P = 0.03). The number with positive serum human chorionic gonadotrophin/cycle decreased significantly with increasing BMI (P < 0.01). The ongoing pregnancy rate/cycle among the obese women was lower (20.8% versus 28.3% in normal-weight women; P = 0.04). Live-birth rate per cycle was 15.2% versus 21.5%. Multiple logistic regression analysis showed that the only independent predictors of live birth were women's age (P = 0.037), women's BMI (P = 0.034) and men's age (P = 0.040). (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

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