Ovarian stimulation in polycystic ovary syndrome patients: the role of body mass index

REPRODUCTIVE BIOMEDICINE ONLINE

卷:18

Article

Orvieto, Raoul^1,2  Nahum, Ravit^1,2  Meltcer, Simion^1,2  Homburg, Roy^1,2  Rabinson, Jacob^1,2  Anteby, Eyal Y.^1,2  Ashkenazi, Jacob^3,4 

[1] Barzilai Govt Hosp, Dept Obstet & Gynecol, Ashqelon, Israel

[2] Ben Gurion Univ Negev, Sch Med, Beer Sheva, Israel

[3] Helen Schneider Hosp Women, Dept Obstet & Gynecol, Rabin Med Ctr, Petah Tiqwa, Israel

[4] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

关键词: body mass index;    GnRH agonist;    GnRH antagonist;    IVF outcome;    PCOS;    pregnancy;   

DOI  :  10.1016/S1472-6483(10)60090-9

来源: Elsevier

【 摘 要 】

In all attempt to examine whether body mass index (BMI) may influence IVF outcome in polycystic ovary syndrome (PCOS) patients undergoing ovarian stimulation with either gonadotrophin-releasing hormone (GnRH)-agonist (agonist group) or antagonist (antagonist group), 100 IVF cycles were studied: 35 in the agonist and 65 in the antagonist groups. In both agonist and antagonist groups, patients with BMI <= 25 kg/m(2) had a significantly higher fertilization rate compared with patients with BMI > 25 kg/m(2) (P < 0.02 and P < 0.01, respectively). Lean patients (BMI <= 25) undergoing ovarian Stimulation using the GnRH-agonist, demonstrated the highest pregnancy rate. In conclusion, in this series of PCOS patients undergoing IVF-embryo transfer cycles, ovarian stimulation utilizing the midluteal long GnRH-agonist suppressive protocol yielded a higher pregnancy rate in lean patients, probably due to its ability to lower the high basal LH milieu and its detrimental effect on oocyte quality and implantation potential.

【 授权许可】

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