Role of dehydroepiandrosterone in improving oocyte and embryo quality in IVF cycles

REPRODUCTIVE BIOMEDICINE ONLINE

卷:28

Article

Zangmo, Rinchen¹  Singh, Neeta¹  Kumar, Sunesh¹  Vanamail, Perumal¹  Tiwari, Abanish¹ 

[1] All India Inst Med Sci, Dept Obstet & Gynecol, New Delhi, India

关键词: dehydroepiandrosterone;    embryos;    infertility;    in vitro fertilization;    oocytes;    ovarian reserve;   

DOI  :  10.1016/j.rbmo.2014.01.019

来源: Elsevier

【 摘 要 】

The purpose of this study was to evaluate the role of dehydroepiandrosterone (DHEA) on the number and quality of oocytes and embryos in poor responders undergoing IVF cycles. A total of 50 patients with a history of poor ovarian response in the previous cycle(s) were enrolled in a prospective cohort study. They were treated with oral micronized DHEA 25 mg three times a day for 4 months. Oocyte and embryo number and quality were recorded before and after treatment. The results were analysed using Student's paired t-test. After treatment with DHEA, a significant increase in number of mature follicles was seen in the post treatment period (<= 35 years P < 0.001; >= 36 years P = 0.002). There were significant increases in numbers of oocytes retrieved, fertilization rates and, consequently, the total number of embryos available. More embryos were vitrified among patients <= 35 years (P < 0.001) post treatment, and clinical pregnancy rate in this group was 26.7%. DHEA treatment resulted in a higher number of oocytes retrieved, oocytes fertilized, embryos overall and of grade-I embryos. It can help in increasing pregnancy rate in poor responders. (C) 2014, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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