Impact of the outcome of fresh blastocyst transfer on the subsequent frozen-thawed blastocyst transfer cycle

REPRODUCTIVE BIOMEDICINE ONLINE

卷:35

Article

El-Toukhy, Tarek¹  Kopeika, Julia Y.¹  Beebeejaun, Yusuf¹  El Tokhy, Omar¹  Pundir, Jyotsna²  Khalaf, Yacoub¹ 

[1] Guys & St Thomas Hosp NHS Fdn Trust, Assisted Concept Unit, London, England

[2] St Bartholomews Hosp, Ctr Reprod Med, London, England

关键词: embryo cryopreservation;    endometrium;    frozen cycle outcome;    IVF;   

DOI  :  10.1016/j.rbmo.2017.06.024

来源: Elsevier

【 摘 要 】

The objective of this observational study was to assess the influence of the outcome of fresh blastocyst transfer on the success rate of the subsequent sibling frozen-thawed blastocyst transfer (FBT) cycle. In total, 1639 FBT cycles were divided into two groups: Group A (n = 698) cycles in which a positive pregnancy test result was achieved and Group B (n = 941) cycles in which no pregnancy was achieved in the preceding fresh IVF cycle. Mean age at cryopreservation, basal FSH level, number of oocytes retrieved, number of embryos transferred in the fresh cycle and survival rate of the thawed blastocysts in the FBT cycle were comparable between the two groups. Although significantly more thawed blastocysts were transferred in the FBT cycles in Group B compared with Group A, the live birth rate in Group A was significantly higher compared with Group B. After adjusting for potentially confounding variables, the likelihood of a live birth after FBT was significantly higher when a pregnancy was achieved in the preceding fresh IVF cycle. Achieving a pregnancy after fresh blastocyst transfer is an independent factor influencing the outcome of the subsequent sibling FBT. (C) 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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