Septate, subseptate and arcuate uterus decrease pregnancy and live birth rates in IVF/ICSI

REPRODUCTIVE BIOMEDICINE ONLINE

卷:21

Article

Tomazevic, T.¹  Ban-Frangez, H.¹  Virant-Klun, I.¹  Verdenik, I.¹  Pozlep, B.¹  Vrtacnik-Bokal, E.¹ 

[1] Univ Med Ctr Ljubljana, Reprod Unit, Dept Obstet & Gynecol, SI-1000 Ljubljana, Slovenia

关键词: arcuate uterus;    IVF/ICSI;    live birth rate;    pregnancy rate;    septate uterus;    subseptate uterus;   

DOI  :  10.1016/j.rbmo.2010.06.028

来源: Elsevier

【 摘 要 】

A retrospective matched-control study to evaluate the effect of uterine anomalies on pregnancy rates after 2481 embryo transfers in conventionally stimulated IVF/intracytoplasmic sperm injection (ICSI) cycles. The study group of 289 embryo transfers before and 538 embryo transfers following hysteroscopic resection of a uterine septum was compared with two consecutive embryo transfers in the control group. Groups were matched for age, body mass index, ovarian stimulation, embryo quality, IVF or ICSI and infertility aetiologies. Number of embryos transferred, embryo quality and absence of uterine anomalies significantly predicted the pregnancy rates in the study group: odds ratios (OR) 1.7, 2.6 and 2.5, respectively (P < 0.001). Pregnancy rates after embryo transfer before hysteroscopic metroplasty were significantly lower, both in women with subseptate and septate uterus and in women with arcuate uterus compared with controls. If two or three embryos with at least one best-quality embryo were transferred, the differences were 9.6% versus 43.6%, OR 7.3 (P <0.001) and 20.9% versus 35.5%, OR 2.1 (P < 0.03), respectively. Differences in terms of live birth rates were even more evident: 1.9% versus 38.6%, OR 32 (P < 0.001) and 3.0% versus 30.4%, OR 14 (P < 0.001). After surgery, the differences disappeared. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

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