The fine structure of human germ layers in vivo: clues to the early differentiation of embryonic stem cells in vitro

REPRODUCTIVE BIOMEDICINE ONLINE

卷:23

Article

Sathananthan, Henry¹  Selvaraj, Kamala² 

[1] Monash Univ, Monash Immunol & Stem Cell Labs, Melbourne, Vic 3800, Australia

[2] GG Hosp, Madras, Tamil Nadu, India

关键词: ectoderm;    ectopic embryo;    endoderm;    mesoderm;    primitive streak;    TEM;   

DOI  :  10.1016/j.rbmo.2011.05.004

来源: Elsevier

【 摘 要 】

The fine structure of the three germ layers in human ectopic embryos (stage 7) have been documented by digital light and electron microscopy. The formation of ectoderm, endoderm and mesoderm and notochordal cells, and also the extraembryonic membranes, amnion and yolk sac, are imaged. The germ layers give rise to all the cells and tissues of the human body. Possible clues to the early differentiation of embryonic stem cells (ESC) in vitro were obtained, since these events are more or less mimicked in cultures of ESC derived from the inner cell mass of human blastocysts. The findings are discussed with reference to previous studies on the fine structure of ESC using the same technique. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free