Chromosomal polymorphisms are associated with female infertility and adverse reproductive outcomes after infertility treatment: a 7-year retrospective study

REPRODUCTIVE BIOMEDICINE ONLINE

卷:35

Article

Cheng, Ran^1,2,3  Ma, Yaxian^1,2,3  Nie, Ying^1,2,3  Qiao, Xiaoyong^1,2,3  Yang, Zhilan^1,2,3  Zeng, Rujun^1,2,3  Xu, Liangzhi^1,2,3 

[1] Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, Chengdu 610041, Sichuan, Peoples R China

[2] Chinese Univ Hong Kong, Joint Lab Reprod Med Sichuan Univ, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Sichuan, Peoples R China

关键词: chromosomal polymorphism;    female infertility;    preterm birth;    spontaneous miscarriage;   

DOI  :  10.1016/j.rbmo.2017.03.022

来源: Elsevier

【 摘 要 】

Data from 19,950 women were retrospectively analysed to determine the effect of chromosomal polymorphisms on female infertility and pregnancy outcome; fertile women were used as controls. Frequency of chromosomal polymorphisms and adverse pregnancy outcomes were compared between groups. A significantly higher incidence of chromosomal polymorphisms was found in total infertile patients, and patients with tubal infertility, ovulatory dysfunction, cervical and uterine abnormalities, and unexplained infertility compared with controls 15.53% [P < 0.001], 4.86% [P = 0.012] 5.40% [P <0.001], 5.75% [P < 0.001] and 8.51% [P < 0.001], versus 3.74%, respectively]. Infertile women had a higher incidence of 9qh+ and inv[9] compared with controls [P < 0.001 and P = 0.0271. Logistic regression analysis showed an effect of chromosomal polymorphisms on female infertility (adjusted OR 1.662, 95% CI 1.551 to 1.796, P<0.001). All couples reported a phenotypicallynormal baby. In control and tubal infertility groups, miscarriage rates were higher in women with chromosomal polymorphisms than in women with normal chromosomes (4.95% versus 0.96%, P = 0.001 and 6.17% versus 1.08%, P < 0.001). Preterm birth rate showed a similar trend. Chromosomal polymorphisms adversely affected spontaneous miscarriage rates (adjusted OR 1.625, 95% CI 1.514 to 1.769, P = 0.005). (C) 2017 Reproductive Healthcare Ltd. Published by Elseviertd. All rights reserved.

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