Decreased serum total cholesterol is associated with a history of childhood physical violence in depressed outpatients

PSYCHIATRY RESEARCH

卷:272

Article

Kraav, Siiri-Liisi¹  Tolmunen, Tommi^1,2  Karkkainen, Olli³  Ruusunen, Anu^2,4  Viinamaki, Heimo^1,2  Mantyselka, Pekka^5,6  Koivumaa-Houkanen, Heli^1,2,7,8,9,10  Valkonen-Korhonen, Minna^1,2  Honkalampi, Kirsi¹¹  Herzig, Karl-Heinz^{12,13,14,15,16}  Lehto, Soili M.^1,2,17 

[1] Univ Eastern Finland, Inst Clin Med Psychiat, Kuopio, Finland

[2] Kuopio Univ Hosp, Dept Psychiat, Kuopio, Finland

[3] Univ Eastern Finland, Fac Hlth Sci, Inst Publ Hlth & Clin Nutr, Kuopio, Finland

[4] Deakin Univ, Food & Mood Ctr, IMPACT Strateg Res Ctr, Sch Med,Barwon Hlth, Geelong, Vic, Australia

[5] Univ Eastern Finland, Primary Hlth Care Unit, Kuopio, Finland

[6] Kuopio Univ Hosp, Kuopio, Finland

[7] South Savonia Hosp Dist, Dept Psychiat, Mikkeli, Finland

[8] North Karelia Cent Hosp, Joensuu, Finland

[9] SOTE, Iisalmi, Finland

[10] Lapland Hosp Dist, Rovaniemi, Finland

[11] Univ Eastern Finland, Dept Educ & Psychol, Joensuu, Finland

[12] Univ Oulu, Dept Physiol, Res Unit Biomed, Oulu, Finland

[13] Univ Oulu, Bioctr Oulu, Oulu, Finland

[14] Univ Oulu, MRC, Oulu, Finland

[15] Univ Hosp, Oulu, Finland

[16] Poznan Univ Med Sci, Dept Gastroenterol & Metab, Poznan, Poland

[17] Univ Helsinki, Fac Med, Dept Psychol & Logoped, Helsinki, Finland

关键词: Major depressive disorder;    Childhood trauma;    Cholesterol;    Adverse childhood experiences;    Physical violence;   

DOI  :  10.1016/j.psychres.2018.12.108

来源: Elsevier

【 摘 要 】

Associations between adverse childhood experiences (ACEs) and cholesterol in depressed patients are unclear. Therefore, we compared 78 adult outpatients with major depressive disorder (MDD) with (n = 24) or without (n = 54) experiences of physical violence in childhood. Background data were collected with questionnaires, and total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured from fasting blood samples. Patients with a history of childhood physical violence had lower levels of TC than the control group. No differences were observed in HDL-C, LDL-C, or low-grade inflammation levels between the two groups. In multivariate models, decreased levels of TC were associated with childhood physical violence, and these associations remained significant after adjustments for age, gender, lifestyle, metabolic condition, socioeconomic situation, psychiatric status, suicidality, low-grade inflammation, the chronicity of depression, medications used and somatic diseases. At the 8-month follow-up, the results were essentially the same when the Trauma and Distress Scale (TADS) was used as the measure of ACEs. The specific mechanisms underlying cholesterol alterations associated with ACEs are a topic for future studies. Better understanding of these mechanisms might lead to possible new interventions in the prevention of adverse health effects resulting from ACEs.

【 授权许可】

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