Clinically significant personality traits in individuals at high risk of developing psychosis

PSYCHIATRY RESEARCH

卷:261

Article

Sevilla-Llewellyn-Jones, Julia^1,2,3,4  Camino, Gustavo⁵  Russo, Debra A.¹  Painter, Michelle¹  Montejo, Angel L.⁶  Ochoa, Susana⁷  Jones, Peter B.^1,8  Perez, Jesus^1,6,8,9 

[1] Fulbourn Hosp, Cambridgeshire & Peterborough NHS Fdn Trust, CAMEO Early Intervent Psychosis Serv, Block 7,Ida Darwin Site, Cambridge CB21 5EE, England

[2] Hosp Clin Univ Virgen Victoria, Dept Mental Hlth, Campus Teatinos, Malaga 29010, Spain

[3] Malaga Univ, Fac Psychol, Campus Teatinos, Malaga 29010, Spain

[4] San Carlos Hosp, Inst Psychiat & Mental Health, Av Prof Martin Lago S-N, Madrid 28040, Spain

[5] Community Mental Hlth Team, Gibraltar GX11 1AA, Gibraltar

[6] Univ Salamanca, Univ Hosp Salamanca, IBSAL Neurosci, Dept Psychiat, E-37007 Salamanca, Spain

[7] CIBERSAM, Inst Recerca St Joan de Deu, Parc Sanitari St Joan de Deu, Res Unit, Carrer Antoni Pujadas 42, Barcelona 08830, Spain

[8] Univ Cambridge, Dept Psychiat, Herchel Smith Bldg, Cambridge CB2 0SZ, England

[9] Univ East Anglia, Fac Med & Hlth Sci, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England

关键词: High-risk;    Psychosis;    Personality;    Schizophrenia;   

DOI  :  10.1016/j.psychres.2018.01.027

来源: Elsevier

【 摘 要 】

It is still unclear to what extent personality may influence the development of psychosis. We aimed to explore significant personality traits in individuals at high-risk (HR) for psychosis. Personalities of forty HR individuals and a matched sample of 40 healthy volunteers (HVs) were evaluated with the Millon Multiaxial Inventory (MCMI-III). They were also assessed with the Positive and Negative Symptoms Scale (PANSS), Beck Depression and Anxiety Inventories (BDI-II and BAI), Global Assessment of Functioning (GAF) and Mini-International Neuropsychiatric Interview (MINI 6.0.0). Fisher's exact test was employed to compare frequency of traits. Mann Whitney U test and logistic regression were used to establish relationships between traits and symptoms, and the effect of age, sex and symptoms on such traits. Most HR individuals (97.5%) had at least one significant trait; 75% had personality disorders, mainly depressive, borderline or schizotypal. Only histrionic and narcissistic traits were more prevalent in HVs. Negative symptoms were related to schizoid and paranoid traits. Depression was more severe with borderline traits. Most HR individuals (67.6%) had more than one DSM-IV Axis I diagnosis, mainly depressive/anxiety disorders. Transition rate was low (5%). Certain personality profiles may not be markers for conversions to psychosis but contribute to high morbidity in HR individuals.

【 授权许可】

Free