Basic self-disturbance in subjects at clinical high risk for psychosis: Relationship with clinical and functional outcomes at one year follow-up

PSYCHIATRY RESEARCH

卷:300

Article

Vaernes, Tor Gunnar^1,2  Rossberg, Jan Ivar^3,4  Melle, Ingrid⁴  Nelson, Barnaby^5,6  Romm, Kristin Lie^1,4  Moller, Paul⁷ 

[1] Oslo Univ Hosp, Div Mental Hlth & Addict, Early Intervent Psychosis Advisory Unit South Eas, Oslo, Norway

[2] Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT, Oslo, Norway

[3] Oslo Univ Hosp, Div Mental Hlth & Addict, Psychiat Res Unit, Oslo, Norway

[4] Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway

[5] Orygen, Parkville, Vic, Australia

[6] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic, Australia

[7] Vestre Viken Hosp Trust, Dept Mental Hlth Res & Dev, Div Mental Hlth & Addict, Drammen, Norway

关键词: Anomalous self-experience;    Risk;    UHR;    Schizophrenia;    Schizotypal;    Remission;    Phenomenology;   

DOI  :  10.1016/j.psychres.2021.113942

来源: Elsevier

【 摘 要 】

Basic self-disturbance (BSD) is assumed to drive symptom development in schizophrenia spectrum disorders and in clinical high-risk (CHR) for psychosis. We investigated the relationship between BSD at baseline, assessed with the Examination of Anomalous Self-Experience (EASE), and symptoms and functional outcome after one year in 32 patients, including 26 CHR and six with non-progressive attenuated psychotic symptoms. Correlations between baseline BSD levels and positive, negative and disorganization symptoms, and global functioning level at follow-up were significant. Hierarchical regression analyses revealed that higher levels of baseline BSD predicted more severe positive symptoms and lower global functioning at follow-up, after adjusting for baseline positive symptoms and functioning. Subjects who were not in symptomatic and functional remission after one year had higher levels of BSD and negative symptoms, and lower functioning level, at baseline. Baseline BSD in participants with schizophrenia spectrum diagnoses at follow-up (9 of 12 were schizotypal personality disorder) were at the levels seen in schizotypal disorders in previous studies, but not significantly different from the other participants. Early identification and assessment of BSD may constitute a useful prognostic tool and a signal for therapeutic targets in CHR conditions. Further CHR studies investigating these relationships with larger samples are recommended.

【 授权许可】

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