Levels of lysophosphatidic acid in cerebrospinal fluid and plasma of patients with schizophrenia

PSYCHIATRY RESEARCH

卷:273

Article

Gotoh, Leo^1,2  Yamada, Misa¹  Hattori, Kotaro^3,4  Sasayama, Daimei^3,5  Noda, Takamasa⁶  Yoshida, Sumiko^6,7  Kunugi, Hiroshi³  Yamada, Mitsuhiko¹ 

[1] Natl Ctr Neurol & Psychiat, Dept Neuropsychopharmacol, Natl Inst Mental Hlth, 4-1-1 Ogawahigashi, Kodaira, Tokyo 1878553, Japan

[2] Fukuoka Univ, Fac Med, Dept Psychiat, Lab Neurosci,Jonan Ku, 7-45-1 Nanakuma, Fukuoka, Fukuoka 8140180, Japan

[3] Natl Ctr Neurol & Psychiat, Dept Mental Disorder Res, Natl Inst Neurosci, Kodaira, Tokyo 1878502, Japan

[4] Natl Ctr Neurol & Psychiat, Translat Med Ctr, Tokyo 1878551, Japan

[5] Shinshu Univ, Sch Med, Dept Psychiat, Matsumoto, Nagano, Japan

[6] Natl Ctr Neurol & Psychiat Hosp, Tokyo, Japan

[7] Natl Ctr Neurol & Psychiat, Med Genome Ctr, Tokyo, Japan

关键词: Schizophrenia;    Biomarker;    Lysophosphatidic acid;    PANSS score;   

DOI  :  10.1016/j.psychres.2019.01.052

来源: Elsevier

【 摘 要 】

It is suggested that lysophosphatidic acid (LPA) plays a key role in the pathophysiology of schizophrenia. In this study, we measured LPA levels by enzyme-linked immunosorbent assay in cerebrospinal fluid (CSF) and plasma samples. The participants were 49 patients with schizophrenia and 49 normal healthy controls for CSF study, and 42 patients and 44 controls for plasma study. We found that LPA levels in the patients were not significantly different from those of controls in CSF (controls: 0.189 +/- 0.077 mu M, patients: 0.175 +/- 0.067 mu M; P = 0.318) and plasma samples (controls: 0.131 +/- 0.067 mu M, patients: 0.120 +/- 0.075 mu M; P = 0.465). On the other hand, CSF levels in medicated patients (0.162 +/- 0.061 mu M) were significantly lower than those observed in un-medicated patients (0.224 +/- 0.067 mu M, P = 0.038), suggesting that our findings could be masked by the influence of medication with antipsychotics. Interestingly, we detected significant negative correlation between PANSS scores and plasma LPA levels, especially in males and in unmedicated patients. Our result suggests that LPA levels in CSF and plasma samples would not serve as a diagnostic biomarker, but plasma levels could be used for symptomatic assessment of schizophrenia.

【 授权许可】

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