Acute intravenous administration of ondansetron and m-CPP, alone and in combination, in patients with obsessive-compulsive disorder(OCD): behavioral and biological results

PSYCHIATRY RESEARCH

卷:79

Article

Broocks, A ; Pigott, TA ; Hill, JL ; Canter, S ; Grady, TA ; L'Heureux, F ; Murphy, DL

关键词: obsessive-compulsive disorder;    meta-chlorophenylpiperazine hydrochloride;    ondansetron;    anxiety;    cortisol;    norepinephrine;    serotonin;   

DOI  :  10.1016/S0165-1781(98)00029-8

来源: Elsevier

【 摘 要 】

Obsessive-compulsive disorder (OCD) has been linked to abnormal function of brain serotonin (5-HT) pathways. Since ondansetron is a highly selective 5-HT3 receptor antagonist, the present study was undertaken to investigate 5-HT3 function in OCD. We administered m-CPP (0.08 mg/kg i.v.) and the potent 5-HT3 antagonist, ondansetron (0.15 mg/kg i.v.), to 11 OCD patients. All of the subjects received four separate challenges (m-CPP + placebo, m-CPP + ondansetron, ondansetron + placebo and placebo + placebo). In comparison to placebo, administration of m-CPP was associated with significant behavioral effects, particularly self-rated measures of anxiety, altered self-reality, functional deficit and OCD symptoms. Pretreatment with ondansetron did not affect any of the self-rated behavioral symptoms. After administration of m-CPP relative to placebo, significant increases in plasma cortisol and prolactin were found. These changes were not affected by ondansetron. In conclusion, our results do not support the hypotheses that 5-HT3 receptor-mediated mechanisms modulate m-CPP's behavioral and neuroendocrine effects in patients with OCD. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

【 授权许可】

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