Lipid levels in female patients with affective disorders

PSYCHIATRY RESEARCH

卷:168

Article

Sagud, Marina²  Mihaljevic-Peles, Alma²  Pivac, Nela¹  Jakovljevic, Miro²  Muck-Seler, Dorotea¹ 

[1] Rudjer Boskovic Inst, Div Mol Med, HR-10002 Zagreb, Croatia

[2] Univ Zagreb, Univ Hosp Ctr Zagreb, Dept Psychiat, Zagreb 10000, Croatia

关键词: Major depressive disorder;    Bipolar disorder;    Mania;    Cholesterol;    High-density-lipoprotein cholesterol;    Low-density-lipoprotein cholesterol;    Triglycerides;   

DOI  :  10.1016/j.psychres.2008.06.048

来源: Elsevier

【 摘 要 】

The role of serum lipids [total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG)] in the pathophysiology of mood disorders is not clear. The aim of this study was to determine lipid profiles in patients with affective disorders. The study included medication-free female subjects (41 patients with bipolar disorder, 22 in a manic and 19 in a depressive phase), 34 patients with major depression, and 50 healthy controls. Serum lipid levels were determined using standard laboratory tests. All patients had significantly lower HDL-C values than control subjects. Increased TG levels were found in patients with bipolar disorder compared with healthy subjects. The changes in lipid profiles persisted when data were adjusted for age, smoking and menopausal status. The results revealed no differences in cholesterol and LDL-C levels and body mass index, but significant differences in the ratios of cholesterol/HDL-C and LDL-C/HDL-C (atherogenic index) among groups. Our results suggest that low HDL-C levels and a high atherogenic index might be a hallmark of affective disorders. Since low HDL-C levels could be a risk factor for the development of coronary heart disease. further investigation of lipid metabolism in affective disorders is warranted. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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