Cystatin C and risk of new-onset depressive symptoms among individuals with a normal creatinine-based estimated glomerular filtration rate: A prospective cohort study

PSYCHIATRY RESEARCH

卷:273

Article

Li Haibin^1,2  Wang Anxin³  Qi Gao^1,2  Guo Jin⁴  Li Xia⁵  Wang Wei⁶  Xiang Yutao⁷  Guo Xiuhua^1,2 

[1] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, 10 Xitoutiao, Beijing 100069, Peoples R China

[2] Capital Med Univ, Beijing Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China

[3] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China

[4] Guanghua Grp Pty Ltd, Melbourne, Vic, Australia

[5] La Trobe Univ, Dept Math & Stat, Melbourne, Vic, Australia

[6] Edith Cowan Univ, Sch Med Sci & Hlth, Global Hlth & Genom, Perth, WA, Australia

[7] Univ Macau, Unit Psychiat, Fac Hlth Sci, Macau, Peoples R China

关键词: Cystatin C;    Renal function;    Depressive symptoms;    Elderly;   

DOI  :  10.1016/j.psychres.2019.01.009

来源: Elsevier

【 摘 要 】

The association between cystatin C and depressive symptoms in the general population has not been thoroughly elucidated to date. We investigated the association of cystatin C with new-onset depressive symptoms among individuals with normal creatinine-based estimated glomerular filtration rates (eGFR). In the China Health and Retirement Longitudinal Study, 5111 participants without depressive symptoms or renal dysfunction (eGFR < 60 ml/min/1.73 m(2)) were included. The outcome was new-onset depressive symptoms over 4 years, defined as a score of >= 12 on the 10-item Center for Epidemiologic Studies Depressive Symptoms Scale. The incidence risk ratio (IRR) and 95% confidence interval (CI) were calculated using modified Poisson regression models. During a 4-year follow-up period, 1746 (34.16%) incidents of depressive symptoms occurred. In a multivariable-adjusted model, the risk of incident depressive symptoms was 1.07 (95% CI 1.02-1.11) per-SD change in cystatin C. A greater cystatin C level was associated with a higher risk of new-onset depressive symptoms among subjects with relatively normal renal function.

【 授权许可】

Free