Upregulation of adenosine A2A receptors induced by atypical antipsychotics and its correlation with sensory gating in schizophrenia patients

PSYCHIATRY RESEARCH

卷:200

Article

Zhang, Jie^1,2  Abdallah, Chadi G.²  Wang, Junqing¹  Wan, Xiaona¹  Liang, Chunlian¹  Jiang, Liyun¹  Liu, Yuzhen⁴  Huang, Haixing⁴  Hong, Xiaohong¹  Huang, Qingjun¹  Wu, Renhua³  Xu, Chongtao¹ 

[1] Shantou Univ Med Coll, Mental Hlth Ctr, Shantou 515043, Guangdong, Peoples R China

[2] Yale Univ Sch Med, Dept Psychiat, New Haven, CT USA

[3] Shantou Univ Med Coll, Dept Med Imaging, Shantou, Guangdong, Peoples R China

[4] Shantou Univ Med Coll, Affiliated Hosp 1, Shantou, Guangdong, Peoples R China

关键词: Sensory gating;    Antipsychotic;    Adenosine;    Schizophrenia;   

DOI  :  10.1016/j.psychres.2012.04.021

来源: Elsevier

【 摘 要 】

Sensory gating deficits have been found in patients with schizophrenia and their unaffected relatives. However, the underlying neurobiological mechanism of this deficit remains unclear. Pre-clinical studies have implicated adenosine in sensory gating deficits in schizophrenia. Therefore, the current study investigated a possible relationship between peripheral adenosine A2A receptor (ADORA2A) and sensory gating indices (P50 measures) in medication-free schizophrenia (n = 31) and healthy (n = 21) groups. The effects of six-week antipsychotic treatment were examined. At baseline, schizophrenia patients showed impaired sensory gating compared to healthy controls. However, there was no significant difference in ADORA2A gene expression among groups. In addition, ADORA2A expression was not correlated with sensory gating at any time point. Following treatment, we found a significant upregulation of ADORA2A expression. Intriguingly, we observed a significant positive association between ADORA2A upregulation and baseline P50 amplitudes in the schizophrenia group. A main finding of the current pilot study is the upregulation of ADORA2A expression following treatment with antipsychotics. In addition, this upregulation was predicted by baseline P50 amplitude, an observation that awaits replication in an expanded sample. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

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