Moderation of the relationship between Toxoplasma gondii seropositivity and trait impulsivity in younger men by the phenylalanine-tyrosine ratio

PSYCHIATRY RESEARCH

卷:270

Article

Peng, Xiaoqing^1,2  Brenner, Lisa A.^3,4,5,6,7  Mathai, Ashwin J.^1,2  Cook, Thomas B.^8,9  Fuchs, Dietrnar¹⁰  Postolache, Nadine¹  Groer, Maureen W.¹¹  Pandey, Janardan P.¹²  Mohyuddin, Farooq²  Giegling, Ina¹³  Wadhawan, Abhishek^1,2  Hartmann, Annette M.¹³  Konte, Bettina¹³  Brundin, Lena^14,15  Friedl, Marion¹³  Stiller, John W.^1,2  Lowry, Christopher A.^{3,7,16,17,18,19}  Rujescu, Dan¹³  Postoache, Teodor T.^1,3,7,20 

[1] Univ Maryland, Mood & Anxiety Program, Sch Med, Baltimore, MD 21201 USA

[2] St Elizabeth Hosp, Psychiat Residency Training Program, Washington, DC USA

[3] Educ & Clin Ctr MIRECC Suicide Prevent, Rocky Mt Mental Illness Res, Denver, CO USA

[4] Univ Colorado, Dept Psychiat, Anschutz Med Campus, Denver, CO 80202 USA

[5] Univ Colorado, Dept Phys Med & Rehabil, Anschutz Med Campus, Denver, CO 80202 USA

[6] Univ Colorado, Dept Neurol, Anschutz Med Campus, Denver, CO 80202 USA

[7] Mil & Veteran Microbiome Consortium Res & Educ MV, Denver, CO USA

[8] Mercyhurst Univ, Dept Publ Hlth, Erie, PA USA

[9] Mercyhurst Univ, Mercyhurst Inst Publ Hlth, Erie, PA USA

[10] Innsbruck Med Univ, Bioctr, Div Biol Chem, Innsbruck, Austria

[11] Univ S Florida, Coll Nursing, Tampa, FL USA

[12] Med Univ South Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA

[13] Martin Luther Univ Halle Wittenberg, Dept Psychiat, Halle, Germany

[14] Michigan State Univ, Coll Human Med, Div Psychiat & Behav Med, Grand Rapids, MI USA

[15] Van Andel Res Inst, Grand Rapids, MI USA

[16] Univ Colorado Boulder, Dept Integrat Physiol, Boulder, CO USA

[17] Univ Colorado Boulder, Ctr Neurosci, Boulder, CO USA

[18] Univ Colorado, Dept Phys Med & Rehabil, Anschua Med Campus, Denver, CO 80202 USA

[19] Univ Colorado, Ctr Neurosci, Anschua Med Campus, Denver, CO 80202 USA

[20] Mental Illness Res Educ & Clin Ctr VISN 5 MIRECC, VA Capitol Hlth Care Network, Baltimore, MD USA

关键词: Impulsivity;    Toxoplasma gondii;    Phenylalanine;    Tyrosine;    Dopamine precursor;    Tryptophan;    Kynurenine;    Serotonin precursor;   

DOI  :  10.1016/j.psychres.2018.03.045

来源: Elsevier

【 摘 要 】

Previously, we reported that Toxoplasma gondii (T. gondii)-seropositivity is associated with higher impulsive sensation seeking in younger men. As dopaminergic and serotonergic signaling regulate impulsivity, and as T. gondii directly and indirectly affects dopaminergic signaling and induces activation of the kynurenine pathway leading to the diversion of tryptophan from serotonin production, we investigated if dopamine and serotonin precursors or the tryptophan metabolite kynurenine interact with the T. gondii impulsivity association. In 950 psychiatrically healthy participants, trait impulsivity scores were related to T. gondii IgG seropositivity. Interactions were also identified between categorized levels of phenylalanine (Phe), tyrosine (Tyr), Phe:Tyr ratio, kynurenine (Kyn), tryptophan (Trp) and Kyn:Trp ratio, and age and gender. Only younger T. gondii-positive men with a high Phe:Tyr ratio, were found to have significantly higher impulsivity scores. There were no significant associations in other demographic groups, including women and older men. No significant effects or interactions were identified for Phe, Tyr, Kyn, Trp, or Kyn:Trp ratio. Phe:Tyr ratio, therefore, may play a moderating role in the association between T. gondii seropositivity and impulsivity in younger men. These results could potentially lead to individualized approaches to reduce impulsivity, based on combined demographic, biochemical and serological factors.

【 授权许可】

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