A combined effect of two Alzheimer's risk genes on medial temporal activity during executive attention in young adults

NEUROPSYCHOLOGIA

卷:56

Article

Green, Adam E.¹  Gray, Jeremy R.²  DeYoung, Colin G.³  Mhyre, Timothy R.⁴  Padilla, Robert⁴  DiBattista, Amanda M.^1,4  Rebeck, G. William⁴ 

[1] Georgetown Univ, Dept Psychol, Washington, DC 20057 USA

[2] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA

[3] Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA

[4] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20057 USA

关键词: APOE;    CLU;    fMRI;    Executive attention;    Medial temporal lobe;   

DOI  :  10.1016/j.neuropsychologia.2013.12.020

来源: Elsevier

【 摘 要 】

A recent history of failed clinical trials suggests that waiting until even the early stages of onset of Alzheimer's disease may be too late for effective treatment, pointing to the importance of early intervention in young people. Early intervention will require markers of Alzheimer's risk that track with genotype but are capable of responding to treatment. Here, we sought to identify a functional MRI signature of combined Alzheimer's risk imparted by two genetic risk factors. We used a task of executive attention during fMRI in participants genotyped for two Alzheimer's risk alleles: APOE-epsilon 4 and CLU-C. Executive attention is a sensitive indicator of the progression of Alzheimer's even in the early stages of mild cognitive impairment, but has not yet been investigated as a marker of Alzheimer's risk in young adults. Functional MRI revealed that APOE-epsilon 4 and CLU-C had an additive effect on brain activity such that increased combined genetic risk was associated with decreased brain activity during executive attention, including in the medial temporal lobe, a brain area affected early in Alzheimer's pathogenesis. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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