NEUROPSYCHOLOGIA | 卷:48 |
Differential engagement of brain regions within a 'core' network during scene construction | |
Article | |
Summerfield, Jennifer J.1  Hassabis, Demis1  Maguire, Eleanor A.1  | |
[1] UCL, Inst Neurol, Wellcome Trust Ctr Neuroimaging, London WC1N 3BG, England | |
关键词: Scene construction; fMRI; Episodic; Memory; Future thinking; Hippocampus; Autobiographical; Objects; | |
DOI : 10.1016/j.neuropsychologia.2010.01.022 | |
来源: Elsevier | |
【 摘 要 】
Reliving past events and imagining potential future events engages a well-established core network of brain areas. How the brain constructs, or reconstructs, these experiences or scenes has been debated extensively in the literature, but remains poorly understood. Here we designed a novel task to investigate this (re)constructive process by directly exploring how naturalistic scenes are built up from their individual elements. We slowed-down the construction process through the use of auditorily presented phrases describing single scene elements in a serial manner. Participants were required to integrate these elements (ranging from three to six in number) together in their imagination to form a naturalistic scene. We identified three distinct sub-networks of brain areas, each with different fMRI BOLD response profiles, favouring specific points in the scene construction process. Areas including the hippocampus and retrosplenial cortex had a biphasic profile, activating when a single scene element was imagined and when 3 elements were combined together; regions including the intra-parietal sulcus and angular gyrus steadily increased activity from 1 to 3 elements; while activity in areas such as lateral prefrontal cortex was observed from the second element onwards. Activity in these sub-networks did not increase further when integrating more than three elements. Participants confirmed that three elements were sufficient to construct a coherent and vivid scene, and once this was achieved, the addition of further elements only involved maintenance or small changes to that established scene. This task offers a potentially useful tool for breaking down scene construction, a process that may be key to a range of cognitive functions such as episodic memory, future thinking and navigation. (C) 2010 Elsevier Ltd. All rights reserved.
【 授权许可】
Free
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10_1016_j_neuropsychologia_2010_01_022.pdf | 666KB | download |